Building the future by doing more together

NM-OREO: using a NM-(bio)molecule cOrona approach to undeRstand the mEchanisms of tOxicity - a systems biology environment impact study
Coordinator - Mónica Amorim
Programme - Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014 (PTDC/AAG-MAA/4084/2014)
Execution dates - 2016-07-11 - 2020-03-31 (45 Months)
Funding Entity - FCT - Fundação para a Ciência e a Tecnologia
Funding for CESAM - 199980 €
Total Funding - 199980 €
Proponent Institution - Universidade de Aveiro
Participating Institutions
Universidade de Aarhus
Universidade de Rovira e Virgil
Colorado School of Mines

When manufactured nanomaterials (NMs) encounter any environment, they are immediately covered by molecules that form a corona, i.e. a layer around the NM. To date, NM research and development of standardization protocols have mostly focused on pristine and in-use NM. The in situ corona formation on NMs can include binding of abiotic inorganic and organic material. As a result, organisms do not directly interact with bare NMs (pristine), but rather with corona-coated NMs. Nevertheless, there is very little knowledge in this area, especially for environmental species. Thus, developing an understanding of the interactions between the NM, the corona-forming molecules, and the biological impact may very well be critical in evaluating risks associated to NMs. This could subsequently determine the future acceptance of NMs in commercial products.
NM-OREO’s mission is to advance knowledge by providing useful models that support a realistic assessment of environmental risks posed by NMs. In a broader context, this will support the sustainable exploitation of nanotechnology in Europe, the US and worldwide. To address this issue, a highly interdisciplinary team has joined forces to measure, understand and model the impact of coronas on NM interacting with both environmental and biological matrices.

Members on this project
Anna Ammendola
Research Fellow
Vera Lúcia Maria

CESAM Funding: