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PLATOX-In vitro and in vivo investigations to generate validated toxicity data of graphene nanoplatelets vs. a carbon black reference
Coordinator - Otto Creutzenberg
CESAM Responsible researcher - Helena Cristina Correia de Oliveira
Programme - ERA-NET SIINN - Safe Implementation of Innovative Nanoscience and Nanotechnology
Execution dates - 2015-04-10 - 2017-03-31 (24 Months)
Funding Entity - European Commission, National funding by FCT
Funding for CESAM - 73800 €
Total Funding - 382000 €
Proponent Institution - Fraunhofer ITEM, Germany
Participating Institutions
Universidade de Aveiro
BIOTOX Srl, Romania


Graphene family nanoparticles (GFN) are within the group of carbon-based synthetic nanomaterials (as fullerenes, carbon nanotubes ­ CNT) and are currently subject of intense efforts to accelerate their toxicological characterisation. Certain CNT exhibiting rigidness and a needle-like geometry show accordingly a fibre-specific carcinogenicity. Analogically GFN (i.e. graphene nanoplatelets) seem to have a specific deposition behaviour in the alveolar region due to their nano-thickness and respirability although two dimensions are at microscale. The European Commission is currently driving both innovative material science on GFN as well as the safety testing. Existing toxicity data suggest a lower toxic potential for graphenes as compared to CNT. However, the current database on GFN is scarce. This project will compare commercially available graphenes (i. pure carbon; ii. functionalised with hydroxy or carboxyl groups; iii. graphenes/graphits) using a combined in vitro and in vivo approach.




Members on this project
Helena Cristina Correia de Oliveira
Investigador Responsável

CESAM Funding: