|NM-OREO: using a NM-(bio)molecule cOrona approach to undeRstand the mEchanisms of tOxicity - a systems biology environment impact study|
Programme - Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014 (PTDC/AAG-MAA/4084/2014)
Execution dates - 2016-07-11 - 2020-03-31 (45 Months)
Funding Entity - FCT - Fundação para a Ciência e a Tecnologia
Funding for CESAM - 199980 €
Total Funding - 199980 €
Proponent Institution - Universidade de Aveiro
Universidade de Aarhus
Universidade de Rovira e Virgil
Colorado School of Mines
When manufactured nanomaterials (NMs) encounter any environment, they are immediately covered by molecules that form a corona, i.e. a layer around the NM. To date, NM research and development of standardization protocols have mostly focused on pristine and in-use NM. The in situ corona formation on NMs can include binding of abiotic inorganic and organic material. As a result, organisms do not directly interact with bare NMs (pristine), but rather with corona-coated NMs. Nevertheless, there is very little knowledge in this area, especially for environmental species. Thus, developing an understanding of the interactions between the NM, the corona-forming molecules, and the biological impact may very well be critical in evaluating risks associated to NMs. This could subsequently determine the future acceptance of NMs in commercial products.
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