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  • Authors Alves, AC; Monteiro, MS; Machado, AL; Oliveira, M; Boia, A; Correia, A; Oliveira, N; Soares, AMVM; Loureiro, S
  • Author Full Name Alves, Ana Catarina; Monteiro, Marta S.; Machado, Ana Luisa; Oliveira, Mario; Boia, Ana; Correia, Ana; Oliveira, Nuno; Soares, Amadeu M. V. M.; Loureiro, Susana
  • Title Mercury levels in parturient and newborns from Aveiro region, Portugal
  • Nationality internacional
  • Source JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
  • Language English
  • Document Type Article; Proceedings Paper
  • Conference Title 3rd International Conference on Occupational and Environmental Toxicology ( (ICOETox) / 3rd Ibero-American Meeting on Toxicology and Environmental Health International ((IBAMTOX)
  • Conference Date JUN 21-23, 2016
  • Conference Location Porto, PORTUGAL
  • Keywords Plus PRENATAL METHYLMERCURY EXPOSURE; HUMAN PLACENTA; FISH CONSUMPTION; UMBILICAL-CORD; AMNIOTIC-FLUID; FETAL-BRAIN; BLOOD; HAIR; POPULATION; WOMEN
  • Abstract Since the outbreak of methylmercury (MeHg) poisoning in Japan and Iraq, mercury (Hg) is classified as well-established teratogen. The Portuguese region of Aveiro faced some decades ago an environmental Hg contamination due to activities from a chlor-alkali plant. Until now, no apparent evaluation was conducted regarding prenatal exposure to Hg in this area. The main objectives of this study were to: i) assess maternal and fetal exposure to Hg in the Aveiro region using noninvasive biological matrices; ii) examine the influence of variables that may contribute to Hg exposure during pregnancy; and iii) improve knowledge regarding metal accumulation and distribution over the maternal-fetal-placental unit. This study was performed in 50 mother-newborn pairs from the Aveiro district. Total Hg (THg) was quantified in maternal scalp hair, placenta, amniotic membrane, and umbilical cord. Maternal hair presented THg levels with a mean value of 900 ng/g, which is lower than the USEPA and WHO acceptable threshold. Regarding THg levels in placenta and umbilical cord, mean values were similar (decidua basalis: 32.84 ng/g; chorionic plate: 30.18 ng/g; umbilical cord: 30.67 ng/g). The amniotic membrane presented the highest THg levels with a mean concentration of 42.35 ng/g, reaching a maximum of 134.1 ng/g. Further, a significant positive correlation was noted between THg levels found in hair, and all matrices analyzed reinforcing the use of hair in biomonitoring studies with respect to maternal exposure to Hg. In general, levels of THg found in our study were lower than those in previous studies performed in Europe. Consumption of fish rich in selenium and bottled water was negatively correlated with THg levels. Finally, data demonstrated that Hg is capable of crossing the placental barrier and accumulate in placental tissues. Amniotic membrane seemed to play a role in metal detoxification, but further investigations are necessary to examine whether this catabolic process affects Hg accumulation.
  • Author Address [Alves, Ana Catarina; Monteiro, Marta S.; Machado, Ana Luisa; Soares, Amadeu M. V. M.; Loureiro, Susana] Univ Aveiro, Dept Biol, Campus Univ Santiago, P-3810193 Aveiro, Portugal; [Alves, Ana Catarina; Monteiro, Marta S.; Machado, Ana Luisa; Soares, Amadeu M. V. M.; Loureiro, Susana] Univ Aveiro, Ctr Estudos Ambiente & MAR CESAM, Aveiro, Portugal; [Oliveira, Mario; Boia, Ana; Correia, Ana; Oliveira, Nuno] Ctr Hosp Baixo Vouga, Infante D Pedro Hosp, Obstet & Gynecol Dept, EPE, Aveiro, Portugal
  • Reprint Address Monteiro, MS (reprint author), Univ Aveiro, Dept Biol, Campus Univ Santiago, P-3810193 Aveiro, Portugal.
  • E-mail Address mmonteiro@ua.pt
  • ResearcherID Number Loureiro, Susana/B-4462-2008
  • ORCID Number Loureiro, Susana/0000-0002-5393-9623; Monteiro, Marta/0000-0002-1891-7365; Soares, Amadeu/0000-0003-0879-9470; Alves, Ana Catarina/0000-0002-5804-7309; Machado, Ana/0000-0002-5213-6001
  • Funding Agency and Grant Number CNRS/INEE-National Center for Scientific Research/Institute of Ecology and Environment, via LabEx DRIIHM-Dispositif de Recherche Interdisciplinaire sur les Interactions Hommes-Milieux; OHMI-International Observatory Hommes-Milieux through the project (OHM-E) [2]; FCT (Portuguese Science Foundation) [SFRH/BPD/100448/2014, UID/AMB/50017]; FCT/MEC; FEDER within the PT2020 Partnership Agreement and Compete [POCI-01-0145-FEDER-00763]
  • Funding Text This study is supported by CNRS/INEE-National Center for Scientific Research/Institute of Ecology and Environment, via LabEx DRIIHM-Dispositif de Recherche Interdisciplinaire sur les Interactions Hommes-Milieux, and OHMI-International Observatory Hommes-Milieux through the project (OHM-E/2015/Proj. 2)
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  • Cited Reference Count 60
  • Publisher TAYLOR & FRANCIS INC
  • Publisher City PHILADELPHIA
  • Publisher Address 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
  • ISSN 1528-7394
  • Character Source Abbreviation J TOXICOL ENV HEAL A
  • ISO Source Abbreviation J. Toxicol. Env. Health Part A
  • Year Published 2017
  • Volume 80
  • Issue 13-15
  • Special Issue SI
  • Beginning Page 697
  • Ending Page 709
  • Digital Object Identifier (DOI) 10.1080/15287394.2017.1286926
  • Subject Category 13
  • Document Delivery Number Environmental Sciences; Public, Environmental & Occupational Health; Toxicology
  • Unique Article Identifier Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology
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