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title Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity
authors Ferreira, D; Isca, VMS; Leal, P; Seca, AML; Silva, H; Pereira, MD; Silva, AMS; Pinto, DCGA
author full name Ferreira, Daniela; Isca, Vera M. S.; Leal, Pedro; Seca, Ana M. L.; Silva, Helena; Pereira, Maria de Lourdes; Silva, Artur M. S.; Pinto, Diana C. G. A.
title Salicornia ramosissima: Secondary metabolites and protective effect against acute testicular toxicity
nationality internacional
source ARABIAN JOURNAL OF CHEMISTRY
language English
document type Article
author keywords Salicornia ramosissima; Saliramoester; Saliramopyrrole; Saliramophenone; Testicular protection; Histopathology
keywords plus MALE REPRODUCTIVE-SYSTEM; ACID ALKYL ESTERS; FERULIC ACID; STRUCTURAL ELUCIDATION; ANTIOXIDANT; SPERMATOGENESIS; RAT; MICE; OIL
abstract Salicornia ramosissima J. Woods is a salt tolerant plant currently used in the human diet, whose genus not only displays great potential as a crop plant in deserts and highly saline soils, but also has value in traditional medicine and exhibits promising biological activities. The present study was designed to evaluate the effect of S. ramosissima ethanolic extract on carbon tetrachloride (CCl4)-induced testicular damage in a mouse model and identify secondary metabolites present in the tested extract. The histopathological analysis showed that the treatment with the ethanolic extract prior to CCl4 administration prevented significantly the architectural disorder of seminiferous epithelium and germ cell exfoliation. The phytochemical study allowed the identification of known phenolic and aliphatic compounds [ethyl linolenoate (1), sitostanol (2), octadecyl (3) and eicosanyl (4) (E)-ferulates, ethyl (E)-2-hydroxycinnamate (5), scopoletin (6), a triacylglycerol of tetracosanoic acid (7)], and three new compounds: saliramoester, a long chain triester (8), saliram-ophenone, a propiophenone derivative (9) and saliramopyrrole a pyrrole-3-carbaldehyde derivative (10). Their chemical structures were elucidated using detailed spectroscopic studies (1D and 2D NMR and MS). These results enhance the value of S. ramosissima as an excellent source of structurally interesting phytochemicals and as protective agent against testicular toxicity. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
author address [Ferreira, Daniela; Leal, Pedro; Silva, Helena; Pereira, Maria de Lourdes] Univ Aveiro, Dept Biol, Campus Santiago, P-3810193 Aveiro, Portugal; [Ferreira, Daniela; Pereira, Maria de Lourdes] Univ Aveiro, CICECO Aveiro Inst Mat, Campus Santiago, P-3810193 Aveiro, Portugal; [Isca, Vera M. S.; Seca, Ana M. L.; Silva, Artur M. S.; Pinto, Diana C. G. A.] Univ Aveiro, Dept Chem & Organ Chem & Nat & Agrofood Prod QOPN, Campus Santiago, P-3810193 Aveiro, Portugal; [Leal, Pedro; Silva, Helena] Univ Aveiro, Ctr Environm & Marine Studies CESAM, Campus Santiago, P-3810193 Aveiro, Portugal; [Seca, Ana M. L.] Univ Azores, Dept Technol Sci & Dev, Rua Mae Deus, P-9501801 Ponta Delgada, Azores, Portugal
reprint address Pinto, DCGA (reprint author), Univ Aveiro, Dept Chem, Campus Santiago, P-3810193 Aveiro, Portugal.
e-mail address diana@ua.pt
researcherid number Seca, Ana/E-5475-2013
orcid number Seca, Ana/0000-0002-7709-2375; Silva, Helena/0000-0001-8060-2842; Silva, Artur/0000-0003-2861-8286; Pereira, Maria de Lourdes/0000-0001-6703-7869
funding agency and grant number University of Aveiro [FCTUID/QUI/00062/2013, POCI-01-0145-FEDER-007679]; Fundacao para a Ciencia e a Tecnologia (FCT) FCT/MEC [FCTUID/QUI/00062/2013, POCI-01-0145-FEDER-007679]; FEDER [FCOMP-01-0124-FEDER-037271]; Portuguese National NMR Network (RNRMN)
funding text Thanks are due to the University of Aveiro and Fundacao para a Ciencia e a Tecnologia (FCT) FCT/MEC for the financial support of the QOPNA research Unit (FCTUID/QUI/00062/2013) CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 and CESAM, through national founds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement; FCOMP-01-0124-FEDER-037271 and Portuguese National NMR Network (RNRMN).
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publisher ELSEVIER SCIENCE BV
publisher city AMSTERDAM
publisher address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
issn 1878-5352
29-character source abbreviation ARAB J CHEM
iso source abbreviation Arab. J. Chem.
publication date JAN
year published 2018
volume 11
issue 1
beginning page 70
ending page 80
digital object identifier (doi) 10.1016/j.arabjc.2016.04.012
subject category 11
document delivery number Chemistry, Multidisciplinary
unique article identifier Chemistry
CESAM authors