|Corrole based systems for luminescent thermometry at nanoscale|
Programme - Programa Operacional Regional do Centro (02/SAICT/2017)
Execution dates - 2018-07-26 - 2021-07-25 (36 Months)
Funding Entity - FCT/FEEI/OE
Funding for CESAM - 238048 €
Total Funding - 238048 €
Proponent Institution - Universidade de Aveiro
Temperature (T) is a fundamental parameter that affects the behavior of physical, chemical and biological systems in a wide variety of ways. Measuring T is important in many fields: photonic devices, nano/microelectronics, medical diagnostics, nanomedicine. The design of biocompatible temperature nanosensors to measure T in cells and tissues with sufficient accuracy is a challenge. Measuring T will able to monitor and discern subtle T alterations within the cell and to relate them to early detection of disease. One possible approach is to use dye luminescence thermometers. In this sense corroles have remarkable chemical and photophysical properties such fluorescence, phosphorescence and delay thermal fluorescence suitable to be used as dyes. Additionally, the combination of two emitting entities as QDs, in ratiometric thermometers can overcome some drawbacks of mono-emitting sensor. The combination of properties of corroles and quantum dots foresee the preparation of corrole decorated nanocrystals and further encapsulation on bioplymers, as an innovator class of biocompatible ratiometric thermometers with intrinsic dual emitters to be use at nanoscale. This project aims to prepare these systems , evaluate their luminescence properties and their temperature dependence and perform an evaluation of their cytotoxicity in cells.