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FishPhage - Phage therapy: an innovative technology to inactivate pathogenic bacteria in European seabass (Dicentrarchus labrax)
Coordinator - Adelaide Almeida
Programme - VIII Concurso de Cooperação Bilateral entre Portugal e a China
Execution dates - 2017-01-01 - 2019-01-31 (25 Months)
Funding Entity - FCT - Fundação para a Ciência e a Tecnologia; Ministry of Science and Technology of China (MOST)
Funding for CESAM - 10800 €
Proponent Institution - Universidade de Aveiro
Participating Institutions
Department of Food Science and Technology, Shanghai Jiao Tong University, China

One of the major sources of financial loss for the fish farming industry is the development of infections by pathogenic bacteria, especially multidrug-resistant variants. This problem is most prominent in the early stages of fish development, and is difficult to address with traditional antibiotic treatment or vaccination. Alternative environmentally-friendly biological strategies to control bacterial infections need to be implemented in order to increase aquaculture efficiency and reduce environmental impact, avoiding development of drug-resistance.

FishPhage will operationally test an innovative and recently developed phage therapy (PT) procedure, allowing the inactivation of pathogenic bacteria in fish farms. The possibility of inactivating pathogenic bacteria without any risk for the fish and the environment, associated with the low cost of the process, can be an efficient, safe and cost-effective technology. In this project, we will isolate phages in different countries, and construct phage libriary. To get the best candidate, lysis ability of the phage from the libriary will be evaluated. A novel PT will be developed at laboratory scale. Then, evaluation of the novel PT in industrial fish farm venues and optimization of the paramaters will be carried out.

Members on this project
Adelaide Almeida

CESAM Funding: