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title Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity
authors Capela, MN; Tobaldi, DM; Oliveira, C; Pereira, A; Duarte, AS; Seabra, MP; Fernandes, MHV
author full name Capela, M. N.; Tobaldi, D. M.; Oliveira, C.; Pereira, A.; Duarte, A. S.; Seabra, M. P.; Fernandes, M. H. V.
title Bioactivity and antibacterial activity against E-coli of calcium-phosphate-based glasses: Effect of silver content and crystallinity
nationality internacional
language English
document type Article
author keywords Glass; Glass-ceramic; Bioactive; Silver; Antibacterial
abstract In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli. A melt-quenched bioactive glass of the SiO2-CaO-P2O5-MgO system was modified with the addition of 1 and 2 mol% Ag2O and the 1 mol% Ag2O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E-Coli was generally improved with decreasing particle size or increasing Ag2O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases.
author address [Capela, M. N.; Tobaldi, D. M.; Seabra, M. P.; Fernandes, M. H. V.] Univ Aveiro, CICECO Aveiro Inst Mat, Dept Mat & Ceram Engn, Campus Univ Santiago, P-3810193 Aveiro, Portugal; [Oliveira, C.; Pereira, A.; Duarte, A. S.] Univ Aveiro, Dept Biol, Campus Univ Santiago, P-3810193 Aveiro, Portugal; [Oliveira, C.; Pereira, A.; Duarte, A. S.] Univ Aveiro, CESAM, Campus Univ Santiago, P-3810193 Aveiro, Portugal
reprint address Fernandes, MHV (reprint author), Univ Aveiro, CICECO Aveiro Inst Mat, Dept Mat & Ceram Engn, Campus Univ Santiago, P-3810193 Aveiro, Portugal.
researcherid number Oliveira, Claudia/A-7859-2012; Pereira, Anabela/H-4800-2013; Duarte, Ana/A-5212-2009
orcid number Oliveira, Claudia/0000-0002-5947-4361; Pereira, Anabela/0000-0003-2351-1084; Duarte, Ana/0000-0001-6849-6004; V Fernandes, Maria Helena/0000-0002-1240-2512; Capela, M.N./0000-0003-1355-0047; Seabra, Maria Paula/0000-0002-5174-7433; Tobaldi, David Maria/0000-0002-0112-8570
funding agency and grant number project CICECO-Aveiro Institute of Materials [FCT UID/CTM /50011/2013]; national funds through the FCT/MEC; FEDER under the PT Partnership Agreement; Fundo Social Europeu [SFRH/BPD/65820/2009]; Ministerio da Ciencia, Tecnologia e Ensino Superior, Portugal; [CENTRO-07-0924-FEDER-002030]
funding text The authors acknowledge the financial support from CENTRO-07-0924-FEDER-002030
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cited reference count 36
publisher city OXFORD
issn 0272-8842
29-character source abbreviation CERAM INT
iso source abbreviation Ceram. Int.
publication date NOV
year published 2017
volume 43
issue 16
beginning page 13800
ending page 13809
digital object identifier (doi) 10.1016/j.ceramint.2017.07.100
subject category 10
document delivery number Materials Science, Ceramics
unique article identifier Materials Science