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title Bioactivity and antibacterial activity against E. coli of calcium-phosphatebased glasses: Effect of silver content and crystallinity
authors M.N. Capela, D.M. Tobaldi, C. Oliveira, A. Pereira, A.S. Duarte, M.P. Seabra, M.H.V. Fernandes
author full name Capela, Marinélia; Tobaldi, David; Oliveira, Cláudia; Pereira, Anabela; Duarte, Ana; Seabra, Maria; Fernandes, Maria
title Bioactivity and antibacterial activity against E. coli of calcium-phosphatebased glasses: Effect of silver content and crystallinity
nationality internacional
source Ceramics International
language English
document type Article
author keywords Glass; Glass-ceramic; Bioactive; Silver; Antibacterial
abstract In this work we developed improved bioactive glasses and glass-ceramics for biomedical applications, investigating their in vitro bioactivity, biocompatibility and antibacterial properties against E-Coli. A meltquenched bioactive glass of the SiO2-CaO-P2O5-MgO system was modified with the addition of 1 and 2 mol% Ag2O and the 1 mol% Ag2O-containing glasses were then heat treated to produce glass-ceramics. Surface modifications after soaking in SBF and ionic concentration changes showed that addition of silver and crystallization did not affect bioactivity although crystalline phases promoted a decrease in the degradation rate. Biocompatibility of all Ag-containing glasses and glass-ceramics was confirmed for certain samples concentrations. The antibacterial activity of the glasses against E. Coli was generally improved with decreasing particle size or increasing Ag2O. The Ag-containing glass-ceramics with higher content of crystalline phase appears as a promising biocompatible biocidal material with potential applications in bone-related diseases.
author address [C. Oliveira, A. Pereira, A.S. Duarte] Department of Biology & CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; [M.N. Capela, D.M. Tobaldi, M.P. Seabra, M.H.V. Fernandes] Department of Materials and Ceramic Engineering/CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810- 193 Aveiro, Portugal
reprint address M.H.V. Fernandes: Department of Materials and Ceramic Engineering/CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810- 193 Aveiro, Portugal
publication date 2017
year published 2017
volume 43
issue 16
beginning page 13800
ending page 13809
digital object identifier (doi) http://dx.doi.org/10.1016/j.ceramint.2017.07.100
web of science category WoS
subject category WoS
unique article identifier WoS