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  Maria Eugénia Marques da Costa  
  Phone:  
  e-mail: jenny-costa8@hotmail.com  
  Category: phD Student  
  Department: Biology  
  Research group: Stress Biology
 
 
  Direct URL for this page: http://www.cesam.ua.pt/jenny.costa  
     
  Thesis title: Osteomics: Gene signature predictive of resistance to treatment in human Osteosarcoma and validation of mechanisms of resistance
  Supervisor: Nathalie Gaspar, Birgit Geoerger and Conceição Santos
  Category: BO
  Grant type: BD
  Funding entity: FCT
  Grant reference: SFRH/BD/89137/2012
  Start date: 2013-01-03
  End date: 2017-01-03
Academic Career

Degree in Marine Biology and Biotechnology, specialization in Biotechnology at School of Tourism and Maritime Technology, ESTM – IPL (Polytechnic Institute of Leiria) . Principal subjects / occupational skills covered Animal and Plant Biology; Cell culture; Microbiology; Química; Física; Genetics; Cell Biology; Molecular Biology;  Ecology; Biochemistry; Bioinformatics. 


Final Project: Germplasm Conservation and Genetic study of flora species of Peniche Coast and Berlengas, under the guidance of Maria Manuela Sampaio and Clélia Afonso.


Master of Science in Applied Biology, Specialization in Clinical and Environmental Microbiology at University of Aveiro. Principal subjects / occupational skills covered Molecular and Cell Biology; Cell and Tissue Culture;Microbiology and health; Genetics; Diagnostic Methods; Experimental planning and analysis of Biological data.


Master Dissertation Project: Oxidative Stress Induction by Sulforaphane on human Osteosarcoma, supervised by Helena Oliveira, Miguel Oliveira and Conceição Santos


 

Research Interests

Current interest area: In vitro Cell Culture(tumor and primary cells, Cito/genotoxicity in human cells. Cellular and molecular biology. Changes in apoptosis, Cell Cycle regulation, gene expression, detection of micronuclei and DNA damage, oxidative stress pathways, Genetic characterization-genetic profile Oxidative Stress , gene signature


General Research Interests:
 Fitocompostos Health-Cancer, Fitocompostos and phytotherapy, Expression of genes, Cell Biology and Molecular, In vitro tests of antitumor compounds, Osteosarcoma, gene signature


 

Publications
  1. Ferreira de Oliveira J.M.P., Remédios C., Oliveira H., Pinto P., Pinho F., Pinho S., Costa M., Santos C. (2014) Sulforaphane Induces DNA Damage and Mitotic Abnormalities in Human Osteosarcoma MG-63 Cells: Correlation with Cell Cycle and Apoptosis. Nutrition And Cancer-an International Journal. 66, 2, 325-334. (see details) ISI paper
    Link: http://www.tandfonline.com/doi/full/10.1080/01635581.2014.864777#.UvT4K5...
  2. Ferreira de Oliveira JMP, Costa M, Pedrosa T, Pinto P, Remedios C, Oliveira H, Pimentel F, Almeida L, Santos C (2014) Sulforaphane Induces Oxidative Stress and Death by p53-Independent Mechanism: Implication of Impaired Glutathione Recycling. Plos One. 9, 3, e92980 (see details) ISI paper
    Link: http://dx.doi.org/10.1371/journal.pone.0092980
  1. T. Pedrosa, H. Oliveira, S. Pinho, C. Monteiro, C. Remédios, P. Pinto, M. Costa, S. Barros, J.M.P. Ferreira de Oliveira, A. Ascenso, S. Varanda, M. Santos, C. Santos (2013) Evaluation of reactive oxygen species production and mitochondrial membrane potential on adherent cell lines using flow cytometry. (see details)
  2. Costa M, Remédios C, Pinto P, Pinho F, Pedrosa T, Oliveira H, Oliveira M, Santos C (2012) Sulforaphane induces cell cycle arrest and genotoxicity in MG-63 human osteosarcoma cell line. (see details)
  3. Santos C., Oliveira M., Ascenso A., Remédios C., Costa M., Pinto P., Pinho S., Pinho F., Pedrosa T., Oliveira H. (2012) From the cytome to the genome: in vitro assays within the 3Rs perspective. (see details)
    Link: http://www.ua.pt/research/PageText.aspx?id=15254
  4. Remédios C., Costa M., Pinto P., Pinho F., Pedrosa T., Pinho S., Oliveira M., Oliveira H., Santos C. (2012) In vitro assessment of sulforaphane-induced genomic and nuclear damage in an osteosarcoma cell line. (see details)
  5. Costa M., Remédios C., Pinto P., Pinho F., Pedrosa T., Oliveira H., Oliveira M., Santos C. (2012) Cytotoxic effects induced by sulforaphane in human osteosarcoma cell line. (see details)
  6. Remédios C., Costa M., Pinto P., Pinho F, Pedrosa T., Pinho S., Oliveira M., Oliveira H., Santos C. (2012) Genotoxic activity of sulforaphane in an osteosarcoma in vitro model. (see details)
  7. Costa M., Remédios C., Pinto P., Pedrosa T., Pinho F., Pinho S., Oliveira H., Oliveira M., Santos C. (2012) Sulforaphane induced oxidative stress in human osteosarcoma cell line. (see details)
  8. Costa M, Oliveira H, Oliveira M, Santos C. (2012) Sulforaphane present in plants induced antioxidant defenses decrease in human osteosarcoma cell line. (see details)
  9. Ferreira de Oliveira JMP, Costa M, Pedrosa T, Pinto P, Oliveira H, Pimentel F, Almeida L, Santos C (2012) Oxidative stress modulation by sulforaphane in MG-63 cells. (see details)
  10. Oliveira H., Pinto P., Pedrosa T., Pinho F., Remédios C., Barros S., Bastos V., Pinho S., Costa M., Ascenso A., Monteiro C., Almeida T., Santos C. (2011) The potential of flow cytometry to assess genotoxicity and cell cycle blockage imposed by contaminants and drugs: case studies using different biological models. (see details)
  11. Costa, M.E., Jerónimo, A.R., Pratas, D., Rocha, J. (2009) Estudo da quantidade anual de pescado na lota de Peniche (2005, 2006 e 2007). (see details)