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Alexandra Moura

Alexandra Moura

Collaborator

  • Department: Dept. Biology
  • Research Group: Stress Biology
  • ISI Web of KnowledgeSM search factor : ResearcherID=C-8555-2009; ORCID iD =0000-0003-0339-1230


Invited Editor in International Journals

- Dataset Papers in Biology (Hindawi Publishing Corporation) - Bioinformatics section
BioMed Research International (Hindawi Publishing Corporation) - Special Issue on Integrons

Highlights

2012: Key Scientific Article selected by Global Medical Discovery:
Moura A., Pereira C., Henriques I., Correia A. (2012) Novel gene cassettes and integrons in bacteria isolated from an urban wastewater treatment plant. Research in Microbiology. 163, 2, 92–100.

2012: INTEGRALL platform highlighted by Genetic Engineering & Biotechnology News as 'Best of the Web'.

2007: Recommend Article by Faculty of 1000:
Moura A., Henriques I., Ribeiro R., Correia A. (2007) Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant. Journal of Antimicrobial Chemotherapy. 60 , 1243–1250.

Scientific Experience

2014-present: Contract Researcher
Biology of Infection Unit & Evolutionary Microbial Genomics Unit, Institute Pasteur, Paris, France.

2011-2014: Post-Doc Fellow (SFRH/BPD/72256/2010)
Project: Genomic signatures of environmental adaptation in prokaryotes.
CESAM & Department of Biology, University of Aveiro, Portugal;
IRBLLEIDA & Faculty of Medicine, Department of Basic Medical Sciences, University of Lleida, Spain.

2010-2011 (Nov-Apr): Research Student (PTDC/QUI/70523/2006/BI7)
Project: Reconstruction and systems analysis of the reaction networks of reactive oxygen, nitrogen and sulfur species in representative physiological systems.
Centre for Neuroscience and Cell Biology (CNC), Department of Chemistry, University of Coimbra, Portugal.

2009-2010 (Nov-Apr): Research Student (PTDC/QUI/70523/2006/BI3)
Project: Reconstruction and systems analysis of the reaction networks of reactive oxygen, nitrogen and sulfur species in representative physiological systems.
IRBLLEIDA & Faculty of Medicine, Department of Basic Medical Sciences, University of Lleida, Spain.

2009 (Jan-Mar): Supplemental Training on Plasmid Transfer and Replicon Typing.
Julius Kühn Institute - Institute for Epidemiology and Pathogens Diagnostics, Braunschweig, Germany.

2005-2009: PhD student (SFRH/BD/19433/2004)
Thesis: Molecular diversity and transferability of integrons in wastewater environments.
CESAM & Department of Biology, University of Aveiro, Portugal.

2004: Research Student (POCTI/BME/45881/2002/BI)
Project: The prokaryotic flexible gene pool: integrons from environmental origin.
CESAM & Department of Biology, University of Aveiro, Portugal.

2003-2004: Trainee
Theme: Abundance and diversity of bacterial communities in natural environments.
Centre for Cell Biology (CBC) & Department of Biology, University of Aveiro, Portugal.

2003-2004: Technician
Project: Monitoring of water quality in Ria de Aveiro estuarine system.
Centre for Coastal and Maritime Zones (CZCM) & Department of Biology, University of Aveiro, Portugal.

2002-2003: Final Year Project in Microbiology and Genetics
Themes: Environmental metagenomes as antibiotic resistance reservoirs: development and validation of a PCR- and hybridization-based detection systems for beta-lactamase genes; Genomic location of beta-lactam resistance genes in Serratia fonticola UTAD54.
Centre for Cell Biology (CBC) & Department of Biology, University of Aveiro, Portugal.

Citation Metrics

Research groups

Molecular Microbiology Lab (Prof. António Correia, University of Aveiro, Portugal)

Systems Biology and Bioinformatics Research Group (Prof. Rui Alves, University of Lleida, Spain)

Education

2011: PhD Biology, University of Aveiro, Aveiro, Portugal (approved unanimously).
2004: BSc Biology, University of Aveiro, Aveiro, Portugal (final classification of 16 out of 20).


Complementary  Education in Computational Biology:


2013: GTPB Course on Automated and Reproducible Analysis of NGS data - Instituto Gulbenkian de Ciência, Oeiras, Portugal.
2012: GTPB Course on Bioinformatics using Python - Instituto Gulbenkian de Ciência, Oeiras, Portugal.
2011: EMBO Course on Bioinformatics and Comparative Genomic Analysis - Institute Pasteur, Paris, France.
2011: EMBL Bioinformatics Roadshow – Research Centre in Biodiversity and Genetic Resources, Porto, Portugal.

Research Interests

- Next-generation epidemiology
- Genome evolution and environmental adaptation
- Mechanisms of antibiotic resistance
- Horizontal gene transfer
- Dissemination of resistance determinants in the environment

Scientific Supervision

In progress
Concluded

Projects

In progress
Concluded
  • GEMOVE: Genes in motion: Mobile genes in microbial communities, how to catch them? See more
  • PhytoMarsh - The phytosphere of salt-marsh plants: an underexplored microbial hot-spot See more
  • SEAGULL- Identification of nonpoint sources of faecal pollution in a natural environment: contributing data for risk assessment See more

Publications

WoS Papers (17)
Tacão M., Moura A., Alves A., Henriques I., Saavedra M.J., Correia A. (2005) Evaluation of 16S-rDNA- and gyrB-DGGE for typing members of the genus Aeromonas. In: Research Interests. Fems Microbiology Letters. 1, 246, 11-18.
Henriques I., Moura A., Alves A., Saavedra M.J., Correia A. (2006) Analysing diversity among beta-lactamase encoding genes in aquatic environments. In: Research Interests. Fems Microbiology Ecology. 56, 418-429.
Henriques I., Moura A., Alves A., Saavedra M. J., Correia A. (2004) Molecular characterization of a novel class a beta-lactamase, SFC-1, from Serratia fonticola UTAD54. In: Research Interests. Antimicrobial Agents And Chemotherapy . 48, 2321-2324.
de Figueiredo D.R., Pereira M.J., Moura A., Silva L., Bárrios S., Fonseca F., Henriques I., Correia A. (2007) Bacterial community composition over a dry winter in meso- and eutrophic Portuguese water bodies. In: Research Interests. Fems Microbiol Ecol. 59, 3, 638–650
Moura A., Tacão M., Henriques I., Dias J., Ferreira P., Correia A. (2009) Characterization of bacterial diversity in two aerated lagoons of a wastewater treatment plant using PCR-DGGE analysis. In: Research Interests. Microbiological Research. 164, 560-569.
Moura A., Henriques I., Ribeiro R., Correia A. (2007) Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant. In: Research Interests. Journal Of Antimicrobial Chemotherapy. 60 , 1243–1250
Calheiros C., Duque A., Moura A., Henriques I., Correia A., Rangel A., Castro P. (2009) Substrate effect on bacterial communities from constructed wetlands planted with Typha latifolia treating industrial wastewater. In: Research Interests. Ecological Engineering. 35, 744-753.
Moura A., Soares M., Pereira C., Leitão N., Henriques I., Correia A. (2009) INTEGRALL: a database and search engine for integrons, integrases and gene cassettes. In: Research Interests. Bioinformatics. 25, 1096–1098
Calheiros C., Duque A., Moura A., Henriques I., Correia A., Rangel A., Castro P. (2009) Bacterial community dynamics in two-stage constructed wetlands with different plants for industrial wastewater treatment. In: Research Interests. Bioresource Technology. 100, 3228-3235.
Moura A., Henriques I., Smalla K., Correia A. (2010) Wastewater bacterial communities bring together broad-host range plasmids, integrons and a wide diversity of uncharacterized gene cassettes. In: Research Interests. Research In Microbiology. 161, 58-66.
Moura A., Pereira C., Henriques I., Correia A. (2012) Novel gene cassettes and integrons in bacteria isolated from an urban wastewater treatment plant. In: Research Interests. Research In Microbiology. 163, 2, 92–100
Moura A., Oliveira C., Henriques I., Smalla K., Correia A. (2012) Broad diversity of conjugative plasmids in integron-carrying bacteria from wastewater environments. In: Research Interests. Fems Microbiology Letters. 330, 2, 157-164.
Moura A., Jové T., Ploy M.C., Henriques I., Correia A. (2012) Diversity of gene cassette promoters in class 1 integrons from wastewater environments. In: Research Interests. Applied And Environmental Microbiology. 78, 15, 5413-5416.
Oliveira C.S, Moura A., Henriques I., Brown C.J., Rogers L.M., Top E.M., Correia A. (2013) Comparative genomics of IncP-1 epsilon plasmids from water environments reveals diverse and unique accessory genetic elements. In: Research Interests. Plasmid. 70, 3, 412–419
Tacão M., Moura A., Correia A., Henriques I. (2014) Co-resistance to different classes of antibiotics among ESBL-producers from aquatic systems. In: Research Interests. Water Research. 48, 100-107.
Moura A., Savageau M.A., Alves R. (2013) Relative Amino Acid Composition Signatures of Organisms and Environments. In: Research Interests. Plos One. 8, 10, e77319
Moura A., Araujo S., Alves M.S., Henriques I., Pereira A., Correia A.C.M. (2014) The contribution of Escherichia coli from human and animal sources to the integron gene pool in coastal waters. In: Research Interests. Frontiers In Microbiology. 5,
Other Papers (0)
Books (0)
Book Chapter (0)
Thesis (1)
Moura Alexandra (2011) Molecular diversity and transferability of integrons from wastewaters. In: Research Interests. PhD Thesis.
Communications (32)
de Figueiredo D.R., Pereira M.J., Moura A., Silva L., Bárrios S., Fonseca F., Henriques I., Correia A. (2006) Bacterial diversity in water bodies from North and Center of Portugal during a dry winter – eutrophication enhancement risk. In: Research Interests.
de Figueiredo D.R., Pereira M.J., Moura A., Henriques I., Correia A.. (2005) Genotypic characterization and toxic potential of bloom-forming cyanobacteria from Vela Lake (Portugal) – molecular fingerprinting. In: Research Interests.
Moura, A., Henriques I., Correia A. (2006) Detection of integron-carrying bacteria isolated from wastewaters by dot-blot hybridization. In: Research Interests.
Moura A., Henriques I., Alves A., Correia A. (2007) Integron diversity in a wastewater environment. In: Research Interests.
Moura A, Henriques I., Alves A., Correia A. (2006) Prevalence, dissemination and characterization of integrons from a wastewater environment. In: Research Interests.
Moura A., Henriques I., Alves A., Tacão M., Correia A. (2005) Methods for dissection of phylogenetic and molecular diversity in microbial assemblages and its applications. In: Research Interests.
Moura A., Henriques I., Correia A. (2007) The mobile metagenome: recovery of gene cassettes from wastewaters. In: Research Interests.
de Figueiredo D.R., Ferreira R.V., Cerqueira M., Condesso de Melo T., Moura A., Silva R.A., Pereira M.J., Correia A. (2008) Bacterioplankton diversity along the Cértima River and seasonal shifts at Fermentelos Lake - molecular approach vs environmental parameters. In: Research Interests.
de Figueiredo D.R., Moura A., Correia A. (2008) Science communication – an attitude modulator or simply a unidirectional speech?. In: Research Interests.
Moura A. (2008) Detecção de genes bacterianos de resistência a antibióticos beta-lactâmicos em ambientes aquáticos. In: Research Interests.
Calheiros C., Duque A., Henriques I., Moura A., Correia A., Rangel A., Castro P. (2007) Dynamics of microbial communities from constructed wetlands treating tannery wastewater planted with Typha latifolia in different substrates. In: Research Interests.
Moura A., Henriques I., Correia A. (2007) Plasmid transfer frequencies in a slaughterhouse wastewater treatment plant. In: Research Interests.
Oliveira C., Nina J., Moura A., Henriques I., Correia A. (2008) Bacterioneuston versus bacterioplankton: culture independent approach to screen for broad host range plasmids, antibiotic resistance and integron gene sequences. In: Research Interests.
Moura A., Henriques I., Tacão M., Correia A. (2005) Evaluation of wastewaters as hot spots for horizontal gene transfer. In: Research Interests.
Moura A., Henriques I., Saavedra M.J., Correia A. (2005) Chromosomal location of b-lactam resistance genes in Serratia fonticola UTAD54. In: Research Interests.
Moura A., Tacão M., Henriques I., Correia A. (2004) Evaluation by DGGE analysis of seasonal changes of bacterial diversity in a wastewater treatment plant. In: Research Interests.
Henriques I., Moura A., Alves A., Saavedra M.J., Correia A. (2004) Environmental metagenomes as antibiotic resistance reservoirs: development and validation of molecular techniques to evaluate the diversity of beta-lactamase genes. In: Research Interests.
Henriques I., Moura A., Saavedra M.J., Correia A. (2003) Environmental metagenomes as antibiotic resistance reservoirs: development and validation of a PCR-based detection system for beta-lactamase genes. In: Research Interests.
Moura A., Pereira C., Henriques I., Correia A. (2009) Integron diversity in urban wastewaters. In: Research Interests.
Moura A., Soares M., Pereira C., Leitão N., Henriques I., Correia A. (2009) INTEGRALL: the integron database. In: Research Interests.
Moura A., Pereira C., Henriques I., Correia A. (2011) Novel gene cassettes and integrons in environmental antibiotic-resistant bacteria. In: Research Interests.
Moura A., Jové T., Ploy M.C., Henriques I., Correia A. (2011) Diversity of gene cassette promoters in antibiotic-resistant bacteria from wastewater environments. In: Research Interests.
Moura A., Alves R., Salvador A. (2011) Evolutionary adaptation of proteomes towards minimizing susceptibility to damage by reactive oxygen species. In: Research Interests.
Salvador A., Moura A., Alves R. (2011) Proteome reactivities with the hydroxyl radical reflect organisms’ environmental exposure to oxygen. In: Research Interests.
Moura A., Pereira C., Henriques I., Smalla K., Correia A. (2011) A rich and complex integron gene pool in wastewater environments. In: Research Interests.
Salvador A., Moura A., López Escardó D., Alves R. (2012) Evolutionary adaptation to O2 -rich environments decreases proteins’ reactivity with the hydroxyl radical. In: Research Interests.
Moura A, Henriques I, Smalla K, Correia A (2009) Insights into the mobile gene pool of wastewater bacterial communities. In: Research Interests.
Oliveira C.S, Moura A., Henriques I., Rogers L., Brown C, Top E., Correia A (2012) Comparative genomics and resistance phenotypes of IncP-1epsilon plasmids from estuarine waters. In: Research Interests.
Moura A., Savageau M.A., Alves R. (2013) Relative amino acid composition: signatures and co-adaptation among microorganisms and environments. In: Research Interests.
Moura A., Araújo S., Alves M., Henriques I., Correia A., Pereira A. (2013) Integron profiling of antibiotic resistance Escherichia coli strains from a coastal environment. In: Research Interests.
Moura A., Araújo S., Alves M., Henriques I., Pereira A., Correia A. (2013) Plasmid associations with integron-carrying bacteria from a coastal environment. In: Research Interests.
Martins S., Moura A., Oliveira C., Correia A. (2013) The gene pool of sequenced plasmids – what can we learn?. In: Research Interests.
Other Publications (1)
Salvador A., Moura A., Alves R. (2011) Proteome reactivities with the hydroxyl radical reflect organisms’ environmental exposure to oxygen. Proceedings of InForum2011 1:66-71. In: Research Interests.

CESAM - Centro de Estudos do Ambiente e do Mar - Universidade de Aveiro

CESAM Funding: