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Virgília  Sofia  Silva

Virgília Sofia Silva

Post-Doctoral Research Fellow / Invited Professor

  • Department: Biology
  • Research Group: Functional Biodiversity
  • ISI Web of KnowledgeSM search factor : ResearcherID: D-9914-2011
  • Title: Evaluation of neurotoxicity endpoints relevant to ecotoxicology. Supervisor: Carlos Alexandre Sarabando Gravato and Amadeu Mortágua Velho da Maia Soares Category: BO Grant type: BPD Funding entity: FCT Grant reference: SFRH/BPD/110269/2015 Start date: 2016-09-01 End date: 2019-08-31


Prize


  • Award for "Best Communication - Poster" in “The Fifth Keele Meeting on Aluminium”, which took place from 23 to 25 February 2003 at the University of Keele, with the communication entitled “Evaluation of synaptosomal Al3+ retention and synaptic plasma membrane integrity following in vivo aluminium exposure”.


 

SCHOLARSHIPS


  • Masters Scholarship (BM/6579/95) of the Portuguese Board of Scientific and Technological Research.

  • PhD Scholarship from the University of Aveiro.

  • PhD Scholarship (BD/21343/99) from Portuguese Foundation for Science and Technology (PRAXIS XXI).

  • Post-Doc researcher (SFRH/BPD/14677/2003) grant from Fundação para a Ciência e a Tecnologia from 01-1-2006 to 30-4-2013.

  • Post-Doc researcher (BPD/UI89/2340/2013) grant from Aveiro University in the Project 07-ST24-FEDER-002030 from  01-5-2013 to 30-6-2015.

  • Post-Doc researcher (SFRH/BPD/110269/2015) grant from Fundação para a Ciência e a Tecnologia from 01-09-2016 to 31-08-2019.

Positions


  • Invited Assistant Professor (30%) of the Department of Biology, from the University of Aveiro, between September 12, 2016 and September 11, 2018.

  • Invited Assistant Professor (60%) of the Department of Biology, from the University of Aveiro, between September 14, 2015 and August 31, 2016.

  • Invited Assistant Professor (30%) of the Department of Biology, from the University of Aveiro, between September 17, 2012 and January 31, 2013.

  • Invited Assistant Professor (100%) of the Department of Biology, from the University of Aveiro, between July 30, 2011 and July 29, 2012.

  • Invited Assistant Professor (60%) of the Department of Biology, from the University of Aveiro, between February 9, 2009 and July 29, 2011.

  • Invited Assistant Professor (30%) of the Department of Biology, from the University of Aveiro, between October 1, 2007 and September 14, 2008, and between September 15, 2008 and February 8, 2009.

  • Invited Assistant Professor (50%) of the Department of Biology, from the University of Aveiro, between September 13, 2006 and September 12, 2007.

  • Invited Assistant (60%) of the Department of Biology, from the University of Aveiro, between September 22, 2003 and September 21, 2004 and between September 22, 2004 and September 21, 2005.

  • Monitor of the Department of Biology, from the University of Aveiro, during the 2nd semester of the academic year 1996/97.

Scientific activity

Domain of specialization: Cell Biology
Main research field: Toxicology
Other fields: Biochemistry, Cytotoxicity

 

Education


  • First degree in Biology (BSc), University of Aveiro (july, 1995).

  • Master degree in Cell Biology (MSc), Faculty of Science and Technology, University of Coimbra (june, 1998).

  • Ph.D. in Biology, University of Aveiro (december, 2005).

Scientific Supervision

In progress
Concluded

Projects

In progress
Concluded
  • Biomaterials for regenerative medicine. See more
  • EnerBioAlgae: Energy use of biomass in the degraded water resources rich in microalgae See more
  • Nanotechnology for Next Generation Biomedical Implants (NANO/NMed-AT/0115/2007) See more
  • The synaptosome as a screening tool in Ecotoxicology (POCTI/BSE/46721/2002) See more

Publications

WoS Papers (19)
Silva V.S., Duarte A.I., Rego A.C., Oliveira C.R., Gonçalves P.P. (2005) Effect of chronic exposure to aluminium on isoform expression and activity of rat (Na+/K+)ATPase. In: Toxicol. Sci. 2, 88, 485-494.
Silva V.S., Gonçalves P.P. (2003) The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. In: J. Inorg. Biochem. 1, 97, 143-150.
Cordeiro J.M., Silva V.S., Oliveira C.R., Gonçalves P.P. (2003) Aluminium-induced impairment of Ca2+ modulatory action on GABA transport in brain cortex nerve terminals. In: J. Inorg. Biochem. 1, 97, 132-142.
Silva V.S., Cordeiro J.M., Matos M.J., Oliveira C.R., Gonçalves P.P. (2002) Aluminum accumulation and membrane fluidity alteration in synaptosomes isolated from rat brain cortex following aluminum ingestion: effect of cholesterol. In: Neurosci. Res. 2, 44, 181-193.
Silva V.S., Nunes M.A., Cordeiro J.M., Calejo A.I., Santos S., Neves P., Sykes A., Morgado F., Dunant Y., Gonçalves P.P. (2007) Comparative effects of aluminum and ouabain on synaptosomal choline uptake, acetylcholine release and (Na+/K+)ATPase. In: Toxicology. 236, 3, 158-177.
Gonçalves P.P., Silva V.S. (2007) Does neurotransmission impairment accompany aluminium neurotoxicity?. In: J Inorg Biochem . 101, 9, 1291–1338
Nunes M.A., Santos S., Cordeiro J.M., Neves P., Silva V.S., Sykes A., Morgado F., Dunant Y., Gonçalves P.P. (2008) Acetylcholine release and choline uptake by cuttlefish (Sepia officinalis) optic lobe synaptosomes. In: Biol. Bull. . 214, 1, 1-5.
Calejo A.I. R.o.d.r.i.g.u.e.z. .E. (2010) Life and death in aluminium-exposed cultures of rat lactotrophs studied by flow cytometry. In: Cell Biol Toxicol. 26, 4, 341-353.
Singh M.K., Gracio J., LeDuc P., Gonçalves P.P., Marques P.A.A.P., Gonçalves G., Marques F., Silva V.S., Capela e Silva F., Reis J., Potes J., Sousa A. (2010) Integrated biomimetic carbon nanotube composites for in vivo systems. In: Nanoscale. 2, 2855-2863.
Gonçalves P.P., Singh M.K., Silva V.S., Marques F., LeDuc P.R., Grácio J., Marques P.A.A.P., Gonçalves G., Sousa A.C.M. (2011) Automated high-throughput screening of carbon nanotube-based bio-nanocomposites for bone cement applications. In: Pure And Applied Chemistry. 83, 11, 2063-2069.
Calejo A.I., Jorgacevski J., Silva V.S., Stenovec M., Kreft M., Goncalves P.P., Zorec R. (2012) ALUMINIUM-INDUCED CHANGES OF FUSION PORE PROPERTIES ATTENUATE PROLACTIN SECRETION IN RAT PITUITARY LACTOTROPHS. In: Neuroscience. 201, 57-66.
Silva V.S., Oliveira L., Goncalves P.P. (2013) Alteration of aluminium inhibition of synaptosomal (Na+/K+)ATPase by colestipol administration. In: Journal Of Inorganic Biochemistry. 128, 208-214.
Calejo A.I., Reverendo M., Silva V.S., Pereira P.M., Santos M.A.S., Zorec R., Goncalves P.P. (2014) Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications. In: Molecular Biology Reports. 41, 1, 297-307.
Singh M.K., Marques P.A.A.P., Sousa A.C.M., Grácio J.,, Silva V.S., Gonçalves P.P., Ferreira J.M.F., Olhero S. (2009) Biotoxicity study of bone cement based on a functionalised multi-walled carbon nanotube-reinforced PMMA/HAp nanocomposite. In: Int. J. Nano And Biomaterials . 2, 1-5, 442-453.
Silva V.S., Goncalves P.P. (2015) Effect of lysine acetylsalicylate on aluminium accumulation and (Na+/K+)ATPase activity in rat brain cortex synaptosomes after aluminium ingestion. In: Toxicology Letters. 232, 1, 167-174.
Santos N.F., Cicuendez M., Holz T., Silva V.S., Fernandes K.J.S., Vila M., Costa F.M. (2017) Diamond-Graphite Nanoplatelet Surfaces as Conductive Substrates for the Electrical Stimulation of Cell Functions. In: Acs Applied Materials & Interfaces. 9, 2, 1331-1342.
Ayan-Varela M., Perez-Vidal O., Paredes J.I., Munuera J.M., Villar-Rodil S., Diaz-Gonzalez M., Fernandez-Sanchez C., Silva V.S., Cicuendez M., Vila M., Martinez-Alonso A., Tascon J.M.D. (2017) Aqueous Exfoliation of Transition Metal Dichalcogenides Assisted by DNA/RNA Nucleotides: Catalytically Active and Biocompatible Nanosheets Stabilized by Acid-Base Interactions. In: Acs Applied Materials & Interfaces. 9, 3, 2835-2845.
Cicuendez M., Silva V.S., Hortiguela M.J., Matesanz M.C., Vila M., Portoles M.T. (2017) MC3T3-E1 pre-osteoblast response and differentiation after graphene oxide nanosheet uptake. In: Colloids And Surfaces B-biointerfaces. 158, 33-40.
C.I.M. Santos, G. Gonçalves, M. Cicuéndez, I. Mariz, V.S. Silva, H Oliveira, F. Campos, S. I. Vieira, P.A.A.P. Marques, E.M.S. Maçôas, M.G.P.M.S. Neves, J.M.G. Martinho (2018) Biocompatible hybrids based on nanographene oxide covalently linked to glycolporphyrins: Synthesis, characterization and biological evaluation. In: Carbon. 135, 202-214.
Other Papers (0)
Books (0)
Book Chapter (2)
Paula P. Gonçalves, Robert Zorec, and Virgília S. Silva (2016) Aluminum Neurotoxicity: From Subtle Molecular Lesions to Neurological Diseases. In: Ankica Jelenkoviæ. (EDS.), New York. Nova Science Publishers. 15-45. ISBN: 978-1-63484-762-9.
Maria de Lourdes Pereira, José Coelho, Renata Tavares, Henrique M. A. C. Fonseca, Virgília Silva, Paula P. Gonçalves, and Fernando Garcia e Costa (2018) Microscopy Applied to Materials Sciences and Life Sciences. In: Apple Academic Press. 9781351251587.
Thesis (10)
Silva V.S.A.A. (2005) Estudo do papel da (Na+/K+)ATPase na acção neurotóxica do alumínio. In: PhD Thesis.
Silva V.S.A.A. (1998) Efeito da administração oral de alumínio na membrana pré-sináptica: Análise da (Na+/K+)ATPase, ultra-estrutura e aminoácidos livres em sinaptossomas de cérebro do rato. In: MSc Thesis.
Maria João Cerqueira da Silva (2017) Polyaromatic hydrocarbons in hepathic tissues of Etmopterus pusillus and Galeus melastomus: multibiomarker analysis. In: MSc Thesis.
Reis, C. P. S. S. (2011) P2 purinoreceptors signaling in fibroblastos of rat subcutaneous tissue. In: MSc Thesis.
Moraes P. (2007) O efeito do alumínio no crescimento e na actividade de (Na+/K+)ATPase da Escherichia coli. In: MSc Thesis.
Andreia Pereira Coimbra (2017) Estudo da citotoxicidade de grafeno prístino estabilizado com mononucleótido de flavina em pré-osteoblastos e osteoblastos. In: MSc Thesis.
Joana Filipa Pereira Santos (2017) Estudo da biocompatibilidade de pré-osteoblastos e osteoblastos expostos a nano-folhas de MoS2 estabilizadas com mononucleótidos. In: MSc Thesis.
Bárbara Catarina Gonçalves Correia (2017) Determining how membrane phospholipids regulate CNS myelination and myelin composition. In: MSc Thesis.
Daniela Marques Patrício (2017) Implementation of Mammalian two-hybrid system for highthroughput drugs screnning. In: MSc Thesis.
Liliana Oliveira (2012) Efeito do colesterol na actividade da (Na+/K+)ATPase. In: MSc Thesis.
Communications (35)
Silva V.S., Calejo A.I., Gonçalves P.P. (2006) In vitro aluminium effect on GABA and choline uptake by synaptosomes. In:
Nunes M.A., Nunes M.A., Calejo A.I., Calejo A.I., Silva V.S., Cordeiro J.M., Gonçalves P.P., Silva V.S., Dunant Y., Gonçalves P.P. (2006) Aluminium effect on choline uptake by synaptosomes isolated from rat brain cortex, torpedo electrical organ and cuttlefish optic lobe. In:
Santos S.M., Nunes M.A., Cordeiro J.M., Neves P., Silva V.S., Sykes A., Morgado F., Gonçalves P.P. (2005) In vitro aluminium effect on the (Na+/K+) ATPase activity of synaptosomes from Sepia officinalis optic lobes. In:
Silva V.S., Seiça R.M., Gonçalves P.P., Nogueira A.J.A., Oliveira C.R. (2004) Evaluation of aluminium neurotoxicity: effects of colestipol and acetylsalicylic acid. In:
Silva V.S., Furness D.N., Exley C., Gonçalves P.P. (2003) Evaluation of synaptosomal Al3+ retention and synaptic plasma membrane integrity following in vivo aluminium exposure. In:
Cordeiro J.M., Silva V.S., Oliveira C.R., Gonçalves P.P. (2003) Aluminium-induced impairment of Ca2+ modulatory action on GABA transport in brain cortex nerve terminals. In:
Silva V.S., Gonçalves P.P. (2003) A putative mechanism of (Na+/K+)ATPase inhibition by aluminium: a kinetic study. In:
Silva V.S., Seiça R.M., Nogueira A.J.A., Matos M.J., Rego A.C., Oliveira C.R., Gonçalves P.P. (2005) Potential end-points of aluminium neurotoxicity. In:
Nunes M.A., Santos S., Cordeiro J.M., Neves P., Silva V.S., Sykes A., Dunant Y., Morgado F., Gonçalves P.P. (2005) Comparative analysis of aluminium effect on the (Na+/K+) ATPase activity of synaptosomes isolated from rat brain cortex, torpedo electric organ and cuttlefish optic lobe. In:
Silva V.S., Rego A.C., Gonçalves P.P., Oliveira C.R. (2005) In vivo aluminium effect on multiple isoforms of the (Na+/K+)ATPase. In:
Calejo A.I., Silva V.S., Gonçalves M.P. (2006) Alteration of choline and acetylcholine balance in rat brain synaptosomes exposed to aluminium. In:
Silva V.S., Gonçalves P.P. (2002) Mechanism of aluminum-induced inhibition of synaptosomal (Na+/K+)ATPase. In:
Silva V.S., Oliveira C.R., Gonçalves P.P. (2002) Aluminum-induced alterations in presynaptic membrane fluidity and (Na+/K+)ATPase activity. In:
Silva V.S., Gonçalves P.P. (2007) Neurotransmission impairment: an accomplice to aluminium neurotoxicity?. In:
Calejo A.I. R.o.d.r.i.g.u.e.z. .E. (2009) Evaluation of cell viability in the presence of aluminium in rat pituitary lactotroph cultures. In:
Calejo A.I. .S.i.l.v.a. .V.S. (2011) Aluminium effect on prolactin secretion. In:
Silva V.S. (2000) Administração oral de alumínio altera a fluidez da membrana plasmática de sinaptossomas isolados de córtex cerebral de ratos. In:
Silva V.S., Gonçalves P.P. (1997) Effect of dietary aluminium on synaptosomal (Na+/K+)ATPase. In:
Silva V.S., Castro M., Gonçalves P.P. (2011) New insight on the (Na+/K+)ATPase inhibition by aluminium. In:
Silva V.S., Gonçalves P.P. (2010) Evaluation of aluminium neurotoxicity: Effect of cholesterol. In:
Gonçalves P.P., Silva V.S., Marques F., Marques A., LeDuc F. R. , Singh M.K., Grácio J., Marques P.A.A.P., Gonçalves G., Sousa A.C.M. (2010) Automated high-throughput screening of orthopaedic bioactive materials through cell morphology approaches. In:
Bdikin I., Marques F., Silva V.S., Gonçalves P.P., Singh M.K., Grácio J. (2010) High resolution atomic force microscopy of MG63 cells on composite substrates. In:
Silva V.S., Gonçalves P.P. (2001) Synaptosomal (Na+/K+)ATPase under aluminium intoxication: a kinetic study. In:
Silva V.S., Cordeiro J.M., Oliveira C.R., Gonçalves P.P. (2000) Relationship between (Na+/K+)ATPase activity and membrane fluidity in synaptosomes isolated from rat brain cortex. In:
Silva V.S., Cordeiro J.M., Oliveira C.R., Gonçalves P.P. (2000) Involvement of cholesterol on in vivo aluminium-induced alteration of membrane fluidity in rat brain cortical synaptosomes. In:
Cordeiro J.M., Silva V.S., Oliveira C.R., Gonçalves P.P. (1999) Aluminium-induced alterations in rat brain cortex synaptosomes membrane fluidity. In:
Cordeiro J.M., Silva V.S., Gonçalves P.P., Oliveira C.R. (1998) Aluminium-induced alterations on [Ca2+]in, adenosine triphosphatase activity and membrane fluidity in rat brain cortex synaptosomes. In:
Silva V.S., Gonçalves P.P. (1998) An experimental model to study aluminium neurotoxicity: The (Na+/K+)ATPase activity of brain cortex synaptosomes isolated from aluminium intoxicated rats. In:
Silva V.S., Gonçalves P.P. (1997) In vivo administration of colestipol prevents the inhibitory effect of aluminium on the (Na+/K+)ATPase. In:
Silva V.S., Gonçalves P.P. (1996) Aluminium modifies the rat synaptosomal (Na+/K+)ATPase activity. In:
Silva V.S., Oliveira L., Moraes P., Artykbayeva M., Gonçalves P.P. (2013) Cholesterol effect on (Na+/K+)ATPase activity in the presence of aluminium. In:
Silva V.S., Moraes P., Artykbayeva M. , Gonçalves P.P. (2013) Aluminium effect on Escherichia coli growth in culture. In:
Júlia Gomes, Ana P L Costa, Luis E C Conceição, Carlos Gravato, José Calheiros, Manuela Castro-Cunha, Amadeu M V M Soares, Rui J M Rocha, Virgília S Silva and Andreia C M Rodrigues (2018) EVALUATION OF CELLULAR ENERGY ALLOCATION IN Oncorhynchus mykiss EXPOSED TO THERMAL STRESS. In:
Cátia Azevedo, Rui P. Vieira, Amadeu M.V.M. Soares, Carlos Gravato, Jorge M.S. Goncalves, Andreia C.M. Rodrigues and Virgília Sofia Silva (2018) POLYAROMATIC HYDROCARBONS LEVELS AND OXIDATIVE STRESS IN THE DEEPWATER SHARK Etmopterus spinax (Linnaeus, 1758). In:
Daniela Galvão, Rui P. Vieira, Amadeu M.V.M. Soares, Carlos Gravato, Jorge M.S. Goncalves, Virgília Sofia Silva and Andreia C.M. Rodrigues (2018) BIOACCUMULATION AND NEUROTOXICITY OF MERCURY IN Etmopterus spinax FROM THE SOUTHERN IBERIAN SLOPE. In:
Other Publications (4)
Dutta S., Neto F., Coelho M.C. , Gonçalves P.P., Silva V.S. , Kopyl S., Soares N., Gracio J., Sousa A.C.M. (2011) Analysis of Potential of High Quality Biodiesel Production from Microalgae. Proceedings of the European Biomass Conference and Exhibition, pp. 822-824. In:
M.C. Coelho, F. Neto da Silva, P.P. Gonçalves, V. S. Silva, N. Soares, S. Dutta, S. Kopyl, J. Grácio , A.C.M. Sousa (2012) Avaliação do aproveitamento energético de microalgas para produção de biodiesel, Proceedings of the 6º Encontro Nacional do Colégio de Engenharia Mecânica da Ordem dos Engenheiros. In:
Bdikin I., Marques F., Silva V.S., Gonçalves P.P., Singh M.K., Grácio J. (2010) High resolution atomic force microscopy of MG63 cells on composite substrates. European Cells and Materials. 20(SUPPL.3), 288. In:
Dutta S. , Neto F. , Coelho M.C. , Gonçalves P.P. , Silva V. S , Kopyl S., Soares N., Gracio J., Sousa A.C.M. (2012) Potential Biomass Production from Microalgae Chlorella Vulgaris: Identifying the Limitations in Terms of Energy and Environmental Performance. in Proceedings of the 2nd International Conference on Algal Biomass, Biofuels and Bioproducts, San Diego. In:

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