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  Virgília Sofia Silva  
  Phone: 234 370 983 (ext. 22720)  
  e-mail: vsilva@ua.pt  
  Category: Invited Assitant Professor | Post-Doctoral fellow  
  Department: Biology  
  Research group: Functional Biodiversity
 
ISI Web of KnowledgeSM search factor: ResearcherID: D-9914-2011  
  Direct URL for this page: http://www.cesam.ua.pt/virgiliasilva  
     
  Title: Evaluation of neurotoxicity endpoints relevant to ecotoxicology.
  Supervisor: Carlos Alexandre Sarabando Gravato and Amadeu Mortágua Velho da Maia Soares
  Category: BO
  Grant type: BPD
  Funding entity: FCT
  Grant reference: SFRH/BPD/110269/2015
  Start date: 2016-09-01
  End date: 2019-08-31
Education

  • First degree in Biology (BSc), University of Aveiro (july, 1995).

  • Master degree in Cell Biology (MSc), Faculty of Science and Technology, University of Coimbra (june, 1998).

  • Ph.D. in Biology, University of Aveiro (december, 2005).

Scientific activity
Domain of specialization: Cell Biology
Main research field: Toxicology
Other fields: Biochemistry, Cytotoxicity

 
Positions

  • Invited Assistant Professor (30%) of the Department of Biology, from the University of Aveiro, between September 12, 2016 and September 11, 2018.

  • Invited Assistant Professor (60%) of the Department of Biology, from the University of Aveiro, between September 14, 2015 and August 31, 2016.

  • Invited Assistant Professor (30%) of the Department of Biology, from the University of Aveiro, between September 17, 2012 and January 31, 2013.

  • Invited Assistant Professor (100%) of the Department of Biology, from the University of Aveiro, between July 30, 2011 and July 29, 2012.

  • Invited Assistant Professor (60%) of the Department of Biology, from the University of Aveiro, between February 9, 2009 and July 29, 2011.

  • Invited Assistant Professor (30%) of the Department of Biology, from the University of Aveiro, between October 1, 2007 and September 14, 2008, and between September 15, 2008 and February 8, 2009.

  • Invited Assistant Professor (50%) of the Department of Biology, from the University of Aveiro, between September 13, 2006 and September 12, 2007.

  • Invited Assistant (60%) of the Department of Biology, from the University of Aveiro, between September 22, 2003 and September 21, 2004 and between September 22, 2004 and September 21, 2005.

  • Monitor of the Department of Biology, from the University of Aveiro, during the 2nd semester of the academic year 1996/97.

SCHOLARSHIPS

  • Masters Scholarship (BM/6579/95) of the Portuguese Board of Scientific and Technological Research.

  • PhD Scholarship from the University of Aveiro.

  • PhD Scholarship (BD/21343/99) from Portuguese Foundation for Science and Technology (PRAXIS XXI).

  • Post-Doc researcher (SFRH/BPD/14677/2003) grant from Fundação para a Ciência e a Tecnologia from 01-1-2006 to 30-4-2013.

  • Post-Doc researcher (BPD/UI89/2340/2013) grant from Aveiro University in the Project 07-ST24-FEDER-002030 from  01-5-2013 to 30-6-2015.

  • Post-Doc researcher (SFRH/BPD/110269/2015) grant from Fundação para a Ciência e a Tecnologia from 01-09-2016 to 31-08-2019.

Prize

  • Award for "Best Communication - Poster" in “The Fifth Keele Meeting on Aluminium”, which took place from 23 to 25 February 2003 at the University of Keele, with the communication entitled “Evaluation of synaptosomal Al3+ retention and synaptic plasma membrane integrity following in vivo aluminium exposure”.


 

Scientific Supervision
Master (Main Supervisor): Maria João Cerqueira da Silva
(not a CESAM member)
Master (Main Supervisor): Patrícia Morais
(not a CESAM member)
Master (Main Supervisor): Liliana Oliveira
(not a CESAM member)
Master (Main Supervisor): Joana Filipa Pereira Santos
(not a CESAM member)
Master (Main Supervisor): Andreia Pereira Coimbra
(not a CESAM member)
Master (Co-supervisor): Daniela Patrício
(not a CESAM member)
Master (Co-supervisor): Bárbara Correia
(not a CESAM member)
Master (Co-supervisor): Carla Patrícia da Silva e Sousa Reis
(not a CESAM member)

Pesquisa (Main Supervisor): Rita Adriano Batista
(not a CESAM member)
Pesquisa (Main Supervisor): Ana Rita Guimarães R. Silva
(not a CESAM member)
Pesquisa (Main Supervisor): José Manuel Carita Gonçalves
(not a CESAM member)
Pesquisa (Main Supervisor): Sara Raquel do Souto Pereira
(not a CESAM member)
Pesquisa (Co-supervisor): Ana Margarida Marques
(not a CESAM member)



Projects
Biomaterials for regenerative medicine. [see details]

EnerBioAlgae: Energy use of biomass in the degraded water resources rich in microalgae [see details]

Nanotechnology for Next Generation Biomedical Implants (NANO/NMed-AT/0115/2007) [see details]

The synaptosome as a screening tool in Ecotoxicology (POCTI/BSE/46721/2002) [see details]

Publications
  1. C.I.M. Santos, G. Gonçalves, M. Cicuéndez, I. Mariz, V.S. Silva, H Oliveira, F. Campos, S. I. Vieira, P.A.A.P. Marques, E.M.S. Maçôas, M.G.P.M.S. Neves, J.M.G. Martinho (2018) Biocompatible hybrids based on nanographene oxide covalently linked to glycolporphyrins: Synthesis, characterization and biological evaluation. Carbon. 135, 202-214. (see details) ISI paper
  2. Santos N.F., Cicuendez M., Holz T., Silva V.S., Fernandes K.J.S., Vila M., Costa F.M. (2017) Diamond-Graphite Nanoplatelet Surfaces as Conductive Substrates for the Electrical Stimulation of Cell Functions. Acs Applied Materials & Interfaces. 9, 2, 1331-1342. (see details) ISI paper
    Link: http://pubs.acs.org/doi/ipdf/10.1021/acsami.6b14407
  3. Ayan-Varela M., Perez-Vidal O., Paredes J.I., Munuera J.M., Villar-Rodil S., Diaz-Gonzalez M., Fernandez-Sanchez C., Silva V.S., Cicuendez M., Vila M., Martinez-Alonso A., Tascon J.M.D. (2017) Aqueous Exfoliation of Transition Metal Dichalcogenides Assisted by DNA/RNA Nucleotides: Catalytically Active and Biocompatible Nanosheets Stabilized by Acid-Base Interactions. Acs Applied Materials & Interfaces. 9, 3, 2835-2845. (see details) ISI paper
    Link: http://pubs.acs.org/doi/abs/10.1021/acsami.6b13619
  4. Cicuendez M., Silva V.S., Hortiguela M.J., Matesanz M.C., Vila M., Portoles M.T. (2017) MC3T3-E1 pre-osteoblast response and differentiation after graphene oxide nanosheet uptake. Colloids And Surfaces B-biointerfaces. 158, 33-40. (see details) ISI paper
  5. Silva V.S., Goncalves P.P. (2015) Effect of lysine acetylsalicylate on aluminium accumulation and (Na+/K+)ATPase activity in rat brain cortex synaptosomes after aluminium ingestion. Toxicology Letters. 232, 1, 167-174. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.toxlet.2014.10.014
  6. Calejo A.I., Reverendo M., Silva V.S., Pereira P.M., Santos M.A.S., Zorec R., Goncalves P.P. (2014) Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications. Molecular Biology Reports. 41, 1, 297-307. (see details) ISI paper
    Link: http://link.springer.com/article/10.1007%2Fs11033-013-2862-2#page-1
  7. Silva V.S., Oliveira L., Goncalves P.P. (2013) Alteration of aluminium inhibition of synaptosomal (Na+/K+)ATPase by colestipol administration. Journal Of Inorganic Biochemistry. 128, 208-214. (see details) ISI paper
  8. Calejo A.I., Jorgacevski J., Silva V.S., Stenovec M., Kreft M., Goncalves P.P., Zorec R. (2012) ALUMINIUM-INDUCED CHANGES OF FUSION PORE PROPERTIES ATTENUATE PROLACTIN SECRETION IN RAT PITUITARY LACTOTROPHS. Neuroscience. 201, 57-66. (see details) ISI paper
    Link: http://www.sciencedirect.com/science/article/pii/S0306452211012826
  9. Gonçalves P.P., Singh M.K., Silva V.S., Marques F., LeDuc P.R., Grácio J., Marques P.A.A.P., Gonçalves G., Sousa A.C.M. (2011) Automated high-throughput screening of carbon nanotube-based bio-nanocomposites for bone cement applications. Pure And Applied Chemistry. 83, 11, 2063-2069. (see details) ISI paper
    Link: http://hdl.handle.net/10773/5076
  10. Calejo A.I. R.o.d.r.i.g.u.e.z. .E. (2010) Life and death in aluminium-exposed cultures of rat lactotrophs studied by flow cytometry. Cell Biol Toxicol. 26, 4, 341-353. (see details) ISI paper
    Link: http://www.ncbi.nlm.nih.gov/pubmed/20052527
  11. Singh M.K., Gracio J., LeDuc P., Gonçalves P.P., Marques P.A.A.P., Gonçalves G., Marques F., Silva V.S., Capela e Silva F., Reis J., Potes J., Sousa A. (2010) Integrated biomimetic carbon nanotube composites for in vivo systems. Nanoscale. 2, 2855-2863. (see details) ISI paper
    Link: http://pubs.rsc.org/en/Content/ArticleLanding/2010/NR/c0nr00237b
  12. Singh M.K., Marques P.A.A.P., Sousa A.C.M., Grácio J.,, Silva V.S., Gonçalves P.P., Ferreira J.M.F., Olhero S. (2009) Biotoxicity study of bone cement based on a functionalised multi-walled carbon nanotube-reinforced PMMA/HAp nanocomposite. Int. J. Nano And Biomaterials . 2, 1-5, 442-453. (see details) ISI paper
    Link: http://inderscience.metapress.com/link.asp?id=77171v2382326844
  13. Nunes M.A., Santos S., Cordeiro J.M., Neves P., Silva V.S., Sykes A., Morgado F., Dunant Y., Gonçalves P.P. (2008) Acetylcholine release and choline uptake by cuttlefish (Sepia officinalis) optic lobe synaptosomes. Biol. Bull. . 214, 1, 1-5. (see details) ISI paper
    Link: http://www.biolbull.org/cgi/reprint/214/1/1
  14. Silva V.S., Nunes M.A., Cordeiro J.M., Calejo A.I., Santos S., Neves P., Sykes A., Morgado F., Dunant Y., Gonçalves P.P. (2007) Comparative effects of aluminum and ouabain on synaptosomal choline uptake, acetylcholine release and (Na+/K+)ATPase. Toxicology. 236, 3, 158-177. (see details) ISI paper
  15. Gonçalves P.P., Silva V.S. (2007) Does neurotransmission impairment accompany aluminium neurotoxicity?. J Inorg Biochem . 101, 9, 1291–1338 (see details) ISI paper
    Link: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGG-4NYD8JP-4...
  16. Silva V.S., Duarte A.I., Rego A.C., Oliveira C.R., Gonçalves P.P. (2005) Effect of chronic exposure to aluminium on isoform expression and activity of rat (Na+/K+)ATPase. Toxicol. Sci. 2, 88, 485-494. (see details) ISI paper
    Link: http://toxsci.oxfordjournals.org/cgi/reprint/88/2/485
  17. Silva V.S., Gonçalves P.P. (2003) The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J. Inorg. Biochem. 1, 97, 143-150. (see details) ISI paper
    Link: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TGG-4967MCX-4-...
  18. Cordeiro J.M., Silva V.S., Oliveira C.R., Gonçalves P.P. (2003) Aluminium-induced impairment of Ca2+ modulatory action on GABA transport in brain cortex nerve terminals. J. Inorg. Biochem. 1, 97, 132-142. (see details) ISI paper
    Link: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TGG-4967MCX-3-...
  19. Silva V.S., Cordeiro J.M., Matos M.J., Oliveira C.R., Gonçalves P.P. (2002) Aluminum accumulation and membrane fluidity alteration in synaptosomes isolated from rat brain cortex following aluminum ingestion: effect of cholesterol. Neurosci. Res. 2, 44, 181-193. (see details) ISI paper
    Link: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0H-46SNFYJ-8-...
  1. Maria de Lourdes Pereira, José Coelho, Renata Tavares, Henrique M. A. C. Fonseca, Virgília Silva, Paula P. Gonçalves, and Fernando Garcia e Costa (2018) The Contribution of Light Microscopy to Study Male Reprotoxicity of Cadmium. In: Microscopy Applied to Materials Sciences and Life Sciences. Apple Academic Press. 9781351251587. (see details)
  2. Paula P. Gonçalves, Robert Zorec, and Virgília S. Silva (2016) Aluminium and Imbalance in Neurotransmitter Release . In: Ankica Jelenkoviæ. (EDS.), Aluminum Neurotoxicity: From Subtle Molecular Lesions to Neurological Diseases. New York. Nova Science Publishers. 15-45. ISBN: 978-1-63484-762-9. (see details)
  1. Maria João Cerqueira da Silva (2017) Polyaromatic hydrocarbons in hepathic tissues of Etmopterus pusillus and Galeus melastomus: multibiomarker analysis. MSc Thesis. [supervisor] (see details)
  2. Andreia Pereira Coimbra (2017) Estudo da citotoxicidade de grafeno prístino estabilizado com mononucleótido de flavina em pré-osteoblastos e osteoblastos. MSc Thesis. [supervisor] (see details)
  3. Joana Filipa Pereira Santos (2017) Estudo da biocompatibilidade de pré-osteoblastos e osteoblastos expostos a nano-folhas de MoS2 estabilizadas com mononucleótidos. MSc Thesis. [supervisor] (see details)
  4. Bárbara Catarina Gonçalves Correia (2017) Determining how membrane phospholipids regulate CNS myelination and myelin composition. MSc Thesis. [supervisor] (see details)
  5. Daniela Marques Patrício (2017) Implementation of Mammalian two-hybrid system for highthroughput drugs screnning. MSc Thesis. [supervisor] (see details)
  6. Liliana Oliveira (2012) Efeito do colesterol na actividade da (Na+/K+)ATPase. MSc Thesis. [supervisor] (see details)
  7. Reis, C. P. S. S. (2011) P2 purinoreceptors signaling in fibroblastos of rat subcutaneous tissue. MSc Thesis. [supervisor] (see details)
    Link: http://hdl.handle.net/10773/8025
  8. Moraes P. (2007) O efeito do alumínio no crescimento e na actividade de (Na+/K+)ATPase da Escherichia coli. MSc Thesis. [supervisor] (see details)
    Link: http://ria.ua.pt/handle/10773/764
  9. Silva V.S.A.A. (2005) Estudo do papel da (Na+/K+)ATPase na acção neurotóxica do alumínio. PhD Thesis. (see details)
    Link: http://ria.ua.pt/handle/10773/10763
  10. Silva V.S.A.A. (1998) Efeito da administração oral de alumínio na membrana pré-sináptica: Análise da (Na+/K+)ATPase, ultra-estrutura e aminoácidos livres em sinaptossomas de cérebro do rato. MSc Thesis. (see details)
  1. Silva V.S., Oliveira L., Moraes P., Artykbayeva M., Gonçalves P.P. (2013) Cholesterol effect on (Na+/K+)ATPase activity in the presence of aluminium. (see details)
  2. Silva V.S., Moraes P., Artykbayeva M. , Gonçalves P.P. (2013) Aluminium effect on Escherichia coli growth in culture. (see details)
  3. Calejo A.I. .S.i.l.v.a. .V.S. (2011) Aluminium effect on prolactin secretion. (see details)
  4. Silva V.S., Castro M., Gonçalves P.P. (2011) New insight on the (Na+/K+)ATPase inhibition by aluminium. (see details)
  5. Silva V.S., Gonçalves P.P. (2010) Evaluation of aluminium neurotoxicity: Effect of cholesterol. (see details)
  6. Gonçalves P.P., Silva V.S., Marques F., Marques A., LeDuc F. R. , Singh M.K., Grácio J., Marques P.A.A.P., Gonçalves G., Sousa A.C.M. (2010) Automated high-throughput screening of orthopaedic bioactive materials through cell morphology approaches. (see details)
  7. Bdikin I., Marques F., Silva V.S., Gonçalves P.P., Singh M.K., Grácio J. (2010) High resolution atomic force microscopy of MG63 cells on composite substrates. (see details)
  8. Calejo A.I. R.o.d.r.i.g.u.e.z. .E. (2009) Evaluation of cell viability in the presence of aluminium in rat pituitary lactotroph cultures. (see details)
  9. Silva V.S., Gonçalves P.P. (2007) Neurotransmission impairment: an accomplice to aluminium neurotoxicity?. (see details)
  10. Silva V.S., Calejo A.I., Gonçalves P.P. (2006) In vitro aluminium effect on GABA and choline uptake by synaptosomes. (see details)
  11. Nunes M.A., Nunes M.A., Calejo A.I., Calejo A.I., Silva V.S., Cordeiro J.M., Gonçalves P.P., Silva V.S., Dunant Y., Gonçalves P.P. (2006) Aluminium effect on choline uptake by synaptosomes isolated from rat brain cortex, torpedo electrical organ and cuttlefish optic lobe. (see details)
  12. Calejo A.I., Silva V.S., Gonçalves M.P. (2006) Alteration of choline and acetylcholine balance in rat brain synaptosomes exposed to aluminium. (see details)
  13. Santos S.M., Nunes M.A., Cordeiro J.M., Neves P., Silva V.S., Sykes A., Morgado F., Gonçalves P.P. (2005) In vitro aluminium effect on the (Na+/K+) ATPase activity of synaptosomes from Sepia officinalis optic lobes. (see details)
  14. Silva V.S., Seiça R.M., Nogueira A.J.A., Matos M.J., Rego A.C., Oliveira C.R., Gonçalves P.P. (2005) Potential end-points of aluminium neurotoxicity. (see details)
  15. Nunes M.A., Santos S., Cordeiro J.M., Neves P., Silva V.S., Sykes A., Dunant Y., Morgado F., Gonçalves P.P. (2005) Comparative analysis of aluminium effect on the (Na+/K+) ATPase activity of synaptosomes isolated from rat brain cortex, torpedo electric organ and cuttlefish optic lobe. (see details)
  16. Silva V.S., Rego A.C., Gonçalves P.P., Oliveira C.R. (2005) In vivo aluminium effect on multiple isoforms of the (Na+/K+)ATPase. (see details)
  17. Silva V.S., Seiça R.M., Gonçalves P.P., Nogueira A.J.A., Oliveira C.R. (2004) Evaluation of aluminium neurotoxicity: effects of colestipol and acetylsalicylic acid. (see details)
  18. Silva V.S., Furness D.N., Exley C., Gonçalves P.P. (2003) Evaluation of synaptosomal Al3+ retention and synaptic plasma membrane integrity following in vivo aluminium exposure. (see details)
  19. Cordeiro J.M., Silva V.S., Oliveira C.R., Gonçalves P.P. (2003) Aluminium-induced impairment of Ca2+ modulatory action on GABA transport in brain cortex nerve terminals. (see details)
  20. Silva V.S., Gonçalves P.P. (2003) A putative mechanism of (Na+/K+)ATPase inhibition by aluminium: a kinetic study. (see details)
  21. Silva V.S., Gonçalves P.P. (2002) Mechanism of aluminum-induced inhibition of synaptosomal (Na+/K+)ATPase. (see details)
  22. Silva V.S., Oliveira C.R., Gonçalves P.P. (2002) Aluminum-induced alterations in presynaptic membrane fluidity and (Na+/K+)ATPase activity. (see details)
  23. Silva V.S., Gonçalves P.P. (2001) Synaptosomal (Na+/K+)ATPase under aluminium intoxication: a kinetic study. (see details)
  24. Silva V.S. (2000) Administração oral de alumínio altera a fluidez da membrana plasmática de sinaptossomas isolados de córtex cerebral de ratos. (see details)
  25. Silva V.S., Cordeiro J.M., Oliveira C.R., Gonçalves P.P. (2000) Relationship between (Na+/K+)ATPase activity and membrane fluidity in synaptosomes isolated from rat brain cortex. (see details)
  26. Silva V.S., Cordeiro J.M., Oliveira C.R., Gonçalves P.P. (2000) Involvement of cholesterol on in vivo aluminium-induced alteration of membrane fluidity in rat brain cortical synaptosomes. (see details)
  27. Cordeiro J.M., Silva V.S., Oliveira C.R., Gonçalves P.P. (1999) Aluminium-induced alterations in rat brain cortex synaptosomes membrane fluidity. (see details)
  28. Cordeiro J.M., Silva V.S., Gonçalves P.P., Oliveira C.R. (1998) Aluminium-induced alterations on [Ca2+]in, adenosine triphosphatase activity and membrane fluidity in rat brain cortex synaptosomes. (see details)
  29. Silva V.S., Gonçalves P.P. (1998) An experimental model to study aluminium neurotoxicity: The (Na+/K+)ATPase activity of brain cortex synaptosomes isolated from aluminium intoxicated rats. (see details)
  30. Silva V.S., Gonçalves P.P. (1997) Effect of dietary aluminium on synaptosomal (Na+/K+)ATPase. (see details)
  31. Silva V.S., Gonçalves P.P. (1997) In vivo administration of colestipol prevents the inhibitory effect of aluminium on the (Na+/K+)ATPase. (see details)
  32. Silva V.S., Gonçalves P.P. (1996) Aluminium modifies the rat synaptosomal (Na+/K+)ATPase activity. (see details)
  1. M.C. Coelho, F. Neto da Silva, P.P. Gonçalves, V. S. Silva, N. Soares, S. Dutta, S. Kopyl, J. Grácio , A.C.M. Sousa (2012) Avaliação do aproveitamento energético de microalgas para produção de biodiesel, Proceedings of the 6º Encontro Nacional do Colégio de Engenharia Mecânica da Ordem dos Engenheiros. (see details)
  2. Dutta S. , Neto F. , Coelho M.C. , Gonçalves P.P. , Silva V. S , Kopyl S., Soares N., Gracio J., Sousa A.C.M. (2012) Potential Biomass Production from Microalgae Chlorella Vulgaris: Identifying the Limitations in Terms of Energy and Environmental Performance. in Proceedings of the 2nd International Conference on Algal Biomass, Biofuels and Bioproducts, San Diego. (see details)
    Link: http://transportes-tema.web.ua.pt/publications/149.pdf
  3. Dutta S., Neto F., Coelho M.C. , Gonçalves P.P., Silva V.S. , Kopyl S., Soares N., Gracio J., Sousa A.C.M. (2011) Analysis of Potential of High Quality Biodiesel Production from Microalgae. Proceedings of the European Biomass Conference and Exhibition, pp. 822-824. (see details)
    Link: http://www.etaflorence.it/proceedings/?detail=7490
  4. Bdikin I., Marques F., Silva V.S., Gonçalves P.P., Singh M.K., Grácio J. (2010) High resolution atomic force microscopy of MG63 cells on composite substrates. European Cells and Materials. 20(SUPPL.3), 288. (see details)
    Link: http://www.ecmjournal.org/journal/supplements/vol020supp03/pdf/v020supp0...