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  Sofia Isabel Antunes Gomes Guilherme  
  Phone: +351234370965  
  e-mail: sofia.g.guilherme@ua.pt  
  Category: Post-Doctoral fellow  
  Department: Biology  
  Research group: Ecotoxicology
 
ISI Web of KnowledgeSM search factor: AU=(Guilherme S and Pacheco M)  
   
     
  Title: Comparação da vulnerabilidade ao dano genético induzido por pesticidas em populações de Procambarus clarkii com diferentes historiais de exposição - Identificação de mecanismos de tolerância e resistência
  Supervisor: Professor Doutor Mário Pacheco
  Category: BO
  Grant type: BPD
  Funding entity: Fundação para a Ciência e Tecnologia
  Grant reference: SFRH/BPD/88947/2012
  Start date: 2013-11-01
  End date: 2019-10-31
Academic Degrees

  • 2012, PhD, University of Aveiro

  • 2007, Master in Toxicology, University of Aveiro

  • 2002, First Degree in Biology and Geology, University of Aveiro

Area of scientific activity

  • Aquatic Ecotoxicology

  • Genotoxicity

Scientific Supervision
PhD (Co-supervisor): Ana Raquel Peres Marçal

Master (Main Supervisor): Rodrigo Crespo
(not a CESAM member)
Master (Main Supervisor): Ricardo Costa
(not a CESAM member)
Master (Co-supervisor): Vitória Pereira
(not a CESAM member)

Graduation (Main Supervisor): Graça Oliveira
(not a CESAM member)
Graduation (Main Supervisor): Párástu Oskoei
(not a CESAM member)
Graduation (Main Supervisor): Mélanie Ferreira
(not a CESAM member)
Graduation (Main Supervisor): Tânia Vicente
(not a CESAM member)
Graduation (Co-supervisor): José Portela
(not a CESAM member)
Graduation (Co-supervisor): Guilherme Teixeira
(not a CESAM member)
Internship (Co-supervisor): Párástu Oskoei
(not a CESAM member)
Intership (Co-supervisor): Mélanie Ferreira
(not a CESAM member)
Intership (Co-supervisor): Mélanie Ferreira
(not a CESAM member)



Projects
GENOPES - Mechanisms of DNA damage induced by pesticides in fish and interference of co-exposure to other contaminants [see details]

Publications
  1. Maria, V.L., Ribeiro, M.J., Guilherme, S., Soares, A.M.V.M., Scott-Fordsmand, J.J., Amorim, M.J.B. (2018) Silver (nano)materials cause genotoxicity in enchytraeus crypticus – as determined by the comet assay. Environmental Toxicology And Chemistry. 37, 1, 184-191. (see details) ISI paper
    Link: http://onlinelibrary.wiley.com/doi/10.1002/etc.3944/abstract
  2. Castro D., Mieiro C.L., Coelho J.P., Guilherme S., Marques A., Santos M. A., Duarte A. C., Pereira E., Pacheco M. (2018) Addressing the impact of mercury estuarine contamination in the European eel (Anguilla anguilla L., 1758) – An early diagnosis in glass eel stage based on erythrocytic nuclear morphology . Marine Pollution Bulletin . 127, 733-742. (see details) ISI paper
  3. Cappello T., Brandao F., Guilherme S., Santos M.A., Maisano M., Mauceri A., Canario J., Pacheco M., Pereira P. (2016) Insights into the mechanisms underlying mercury-induced oxidative stress in gills of wild fish (Liza aurata) combining H-1 NMR metabolomics and conventional biochemical assays. Science Of The Total Environment. 548, 13-24. (see details) ISI paper
  4. Marques A., Pilo D., Araujo O., Pereira F., Guilherme S., Carvalho S., Santos M.A., Pacheco M., Pereira P. (2016) Propensity to metal accumulation and oxidative stress responses of two benthic species (Cerastoderma edule and Nephtys hombergii): are tolerance processes limiting their responsiveness?. Ecotoxicology. 25, 4, 664-676. (see details) ISI paper
  5. Marques A., Rego A., Guilherme S., Gaivao I., Santos M.A., Pacheco M. (2016) Evidences of DNA and chromosomal damage induced by the mancozeb-based fungicide Mancozan (R) in fish (Anguilla anguilla L.). Pesticide Biochemistry And Physiology. 133, 52-58. (see details) ISI paper
  6. Pereira R., Guilherme S., Brandao F., Raimundo J., Santos M.A., Pacheco M., Pereira P. (2016) Insights into neurosensory toxicity of mercury in fish eyes stemming from tissue burdens, oxidative stress and synaptic transmission profiles. Marine Environmental Research. 113, 70-79. (see details) ISI paper
  7. Guilherme S., Santos M.A., Gaivao I., Pacheco M. (2015) Genotoxicity evaluation of the herbicide Garlon((R)) and its active ingredient (triclopyr) in fish (Anguilla anguilla L.) using the comet assay. Environmental Toxicology. 30, 9, 1073-1081. (see details) ISI paper
  8. Pereira P., Pablo H., Guilherme S., Carvalho S., Santos M.A., Vale C., Pacheco M. (2014) Metal accumulation and oxidative stress responses in Ulva spp. in the presence of nocturnal pulses of metals from sediment: A field transplantation experiment under eutrophic conditions. Marine Environmental Research. 94, 56-64. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.marenvres.2013.12.005
  9. Guilherme S., Santos M.A., Gaivao I., Pacheco M. (2014) DNA and chromosomal damage induced in fish (Anguilla anguilla L.) by aminomethylphosphonic acid (AMPA)-the major environmental breakdown product of glyphosate. Environmental Science And Pollution Research. 21, 14, 8730-8739. (see details) ISI paper
    Link: http://dx.doi.org/10.1007/s11356-014-2803-1
  10. Marques A., Custodio M., Guilherme S., Gaivao I., Santos M.A., Pacheco M. (2014) Assessment of chromosomal damage induced by a deltamethrin-based insecticide in fish (Anguilla anguilla L.) - A follow-up study upon exposure and post-exposure periods. Pesticide Biochemistry And Physiology. 113, 40-46. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.pestbp.2014.06.003
  11. Marques A., Guilherme S., Gaivao I., Santos M.A., Pacheco M. (2014) Progression of DNA damage induced by a glyphosate-based herbicide in fish (Anguilla anguilla) upon exposure and post-exposure periods - Insights into the mechanisms of genotoxicity and DNA repair. Comparative Biochemistry And Physiology C-toxicology & Pharmacology. 166, 126-133. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.cbpc.2014.07.009
  12. Guilherme S., Santos M.A., Gaivao I., Pacheco M. (2014) Are DNA-damaging effects induced by herbicide formulations (Roundup (R) and Garlon (R)) in fish transient and reversible upon cessation of exposure?. Aquatic Toxicology. 155, 213-221. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.aquatox.2014.06.007
  13. Guilherme S., Gaivão I., Santos M.A., Pacheco M. (2012) DNA damage in fish (Anguilla anguilla) exposed to a glyphosate-based herbicide – Elucidation of organ-specificity and the role of oxidative stress. Mutation Research/genetic Toxicology And Environmental Mutagenesis. 743, 1-9. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.mrgentox.2011.10.017
  14. Costa P., Pereira P., Guilherme S., Barata M., Nicolau L., Santos M.A., Pacheco M., Pousão-Ferreira P. (2012) Biotransformation modulation and genotoxicity in white seabream upon exposure to paralytic shellfish toxins produced by Gymnodinium catenatum. Aquatic Toxicology. 106, 42-47. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.aquatox.2011.08.023
  15. Guilherme, S., Santos, M.A., Barroso, C., Gaivão, I., Pacheco, M. (2012) Differential genotoxicity of Roundup® formulation and its constituents in blood cells of fish (Anguilla anguilla): considerations on chemical interactions and DNA damaging mechanisms. Ecotoxicology. 21, 5, 1381-1390. (see details) ISI paper
  16. Guilherme S. , Gaivão I., Santos M.A., Pacheco M. (2010) European eel (Anguilla anguilla) genotoxic and pro-oxidant responses following short-term exposure to Roundup® - a glyphosate-based herbicide. Mutagenesis. 25, 5, 523-530. (see details) ISI paper
  17. Pereira C., Guilherme S., Barroso C., Verschaeve L., Pacheco M., Mendo S. (2010) Evaluation of DNA Damage Induced by Environmental Exposure to Mercury in Liza aurata Using the Comet Assay. Archives Of Environmental Contamination And Toxicology. 58, 1, 112-122. (see details) ISI paper
    Link: http://www.springerlink.com/content/d52p024362536457/
  18. Guilherme S. , Gaivao I., Santos M.A., Pacheco M. (2009) Tissue specific DNA damage in the European eel (Anguilla anguilla) following a short-term exposure to a glyphosate-based herbicide. Toxicology Letters. 189, Suppl. 1, S212-S212. (see details) ISI paper
    Link: http://dx.doi.org/10.1016/j.toxlet.2009.06.550
  19. Guilherme S., Válega M. , Pereira M.E. , Santos M.A., Pacheco M. (2008) Erythrocytic nuclear abnormalities in wild and caged fish (Liza aurata) along an environmental mercury contamination gradient. Ecotoxicology And Environmental Safety. 70 , 3, 411-421. (see details) ISI paper
    Link: http://www.ncbi.nlm.nih.gov/pubmed/17920119?ordinalpos=2&itool=EntrezSys...
  20. Guilherme S. , Válega M. , Pereira M.E. , Santos M.A., Pacheco M. (2008) Antioxidant and biotransformation responses in Liza aurata under environmental mercury exposure – relationship with mercury accumulation and implications for public health. Marine Pollution Bulletin. 396, 1, 70-78. (see details) ISI paper
    Link: http://www.ncbi.nlm.nih.gov/pubmed/18355877?ordinalpos=1&itool=EntrezSys...
  1. Luís A., Almeida A, Guilherme S. (2004) What do our schoolchildren know about the animal species in their region?. In: International Experiences on Environmental Education: Environmental Education, Comunication and Sustainability. Peter Lang GmbH, Frankfurt Main. (see details)
  1. Guilherme S.A. (2012) Risco genotóxico de herbicidas em Anguilla anguilla L. PhD Thesis. (see details)
    Link: http://hdl.handle.net/10773/10117
  2. Guilherme S. (2007) Indicadores químicos, bioquímicos e citogenéticos em Liza aurata após exposição ambiental a mercúrio. MSc Thesis. (see details)
    Link: http://ria.ua.pt/handle/10773/4503
  1. Castro D. ., Mieiro C.L. ., Coelho J.P. ., Guilherme S. ., Marques A. ., Duarte A.C. ., Pereira E. ., Pacheco M. . (2015) Is metal contamination in estuarine environments endangering European eel (Anguilla anguilla) in their first stage in continental waters? . (see details)
  2. Marques A., Pereira P., Raimundo J., Araújo O., Barata M., Pousão-Ferreira P., Guilherme S., Santos M.A., Pacheco M. (2015) Linking inorganic mercury accumulation in Diplodus sargus blood with the induction of erythrocytic nuclear abnormalities. (see details)
  3. Araújo, O., Marques, A., Piló, D., Pereira, D., Guilherme, S., Carvalho, S., Pacheco, M., Pereira, P. (2015) Searching for associations between mercury sediment loads, accumulated levels in gills and liver of the clam Venerupis philippinarum and oxidative stress profiles. (see details)
  4. Pereira, R., Guilherme, S., Brandão, F., Santos, M.A., Pacheco, M., Pereira, P. (2015) Insights to neurosensory toxicity of mercury in fish eyes provided by accumulated levels, oxidative stress and acetylcholinesterase profiles. (see details)
  5. Carvalho S., Pilo D., Marques A., Araújo O., Guilherme S., Leitao A., Pacheco M.P., Pereira P. (2014) Responses of Venerupis philippinarum (Mollusca, Bivalvia) to metal contamination: do they reflect changes at the community level?. (see details)
  6. Marques, A., Guilherme, S., Gaivão, I., Santos, M. A., Pacheco, M., (2014) Genotoxicity and DNA repair induced by a glyphosate-based herbicide in fish upon exposure and post-exposure periods. (see details)
  7. Guilherme S., Gaivão I., Santos M.A., Pacheco M. (2013) Is DNA damage induced by the herbicide Garlon® in fish (Anguilla anguilla L.) transient and reversible upon cessation of exposure? . (see details)
  8. Marques A., Rego A., Guilherme S., Santos, M.A., Gaivão I., Pacheco M. (2013) Evaluation of DNA integrity in peripheral erythrocytes of Anguilla anguilla upon short-term exposure to the thiram-based fungicide Pomarsol Ultra D®. (see details)
  9. Rego A., Marques A., Guilherme S., Santos, M.A., Gaivão I., Pacheco M. (2013) Chromosomal and DNA damage assessment in fish (Anguilla anguilla L.) exposed to Mancozan® - a carbamate fungicide formulation. (see details)
  10. Guilherme S., Ahmad I., Gaivão I., Santos M., Pacheco M. (2012) DNA damage-induced in fish (Anguilla anguilla) by aminomethylphosphonic acid (AMPA) – the major breakdown product of glyphosate. (see details)
    Link: 20-24 May 2012.
  11. Guilherme S., Ahmad I., Gaivão I., Santos M., Pacheco M. (2012) Genotoxic evaluation of Roundup® formulation and its constituents in fish (Anguilla anguilla). (see details)
  12. Marques, A., Custódio, M., Guilherme, S., Santos, M.A., Pacheco, M. (2012) Evaluation of cytogenetic damage in peripheral erythrocytes of fish (Anguilla anguilla) upon exposure to a deltamethrin-based insecticide. (see details)
  13. Guilherme, S., Santos, M.A., Gaivão, I., Pacheco, M. (2012) Genetic damage induced in the European eel (Anguilla anguilla) following short-term exposure to Garlon®, a triclopyr-based herbicide. (see details)
  14. Guilherme S., Ahmad I., Santos M.A., Gaivão I., Pacheco M. (2012) DNA damage induced in fish (Anguilla anguilla) by aminomethylphosphonic acid (AMPA) - the major breakdown product of glyphosate. (see details)
  15. Pereira P., Guilherme S., Pacheco M., Pousão-Ferreira P., Costa P. (2011) Evidences for genotoxicity of paralytic shellfish toxins produced by Gymnodinium catenatum in white seabream (Diplodus sargus) . (see details)
  16. Guilherme S., Gaivão I., Santos M. A., Pacheco M. (2010) Cytogenetic and DNA damage in European eel (Anguilla anguilla) blood following short-term exposure to realistic levels of Roundup® herbicide. (see details)
  17. Guilherme S., Gaivão I., Santos M. A., Pacheco M. (2010) DNA damage in key tissues of the European eel (Anguilla anguilla) following short-term exposure to Roundup® - a glyphosate-based herbicide. (see details)
  18. Costa P., Pereira P., Barata M., Nicolau L., Guilherme S., Pacheco M., Santos M.A., Pousão-Ferreira P. (2010) Liver EROD and GST activities and erythrocytic nuclear abnormalities following intraperitoneal (i.p.) exposure of white seabream (Diplodus sargus) to paralytic shellfish toxins produced by Gymnodinium catenatum. (see details)
  19. Guilherme S., Gaivão I., Santos M. A., Pacheco M. (2009) Tissue specific DNA damage in the European eel (Anguilla anguilla) following a short-term exposure to a glyphosate-based herbicide. (see details)
  20. Guilherme S., Pereira M. E., Santos M. A., Pacheco M. (2009) Mercury distribution in key tissues of caged fish (Liza aurata) along an environmental mercury contamination gradient. (see details)
  21. Guilherme S., Válega M., Pereira M.E., Santos M.A., Pacheco M. (2008) Muscle mercury levels in Liza aurata under environmental exposure and its implications for public health. (see details)
  22. Guilherme S., Válega M., Pereira M.E., Santos M.A., Pacheco M. (2008) Antioxidant and biotransformation responses in Liza aurata under environmental mercury exposure. (see details)
  23. Mieiro C.L., Guilherme S., Pacheco M., Pereira M.E., Duarte A.C. (2007) Mercury accumulation in Liza aurata along an estuarine contamination gradient. (see details)
  24. Guilherme S., Válega M., Pereira M.E., Santos M.A., Pacheco M. (2007) Genotoxicity of mercury in wild and caged fish (Liza aurata) along an environmental contamination gradient. (see details)
  25. Luís A., Almeida A, Guilherme S. (2003) What do our schoolchildren know about the animal species in their region? First World Environmental Education Congress. (see details)
  26. Marques, A., Guilherme, S., Gaivão, I., Santos, M. A., Pacheco, M., Genotoxicity and DNA repair induced by a glyphosate-based herbicide in fish upon exposure and post-exposure periods. (see details)
  27. Marques A., Pereira P., Raimundo J., Araújo O., Barata M., Pousão-Ferreira P., Guilherme S., Santos M.A., Pacheco M. Linking inorganic mercury accumulation in Diplodus sargus blood with the induction of erythrocytic nuclear abnormalities. (see details)
  28. Araújo, O., Marques, A., Piló, D., Pereira, D., Guilherme, S., Carvalho, S., Pacheco, M., Pereira, P. Searching for associations between mercury sediment loads, accumulated levels in gills and liver of the clam Venerupis philippinarum and oxidative stress profiles. (see details)
  29. Pereira, V., Marques, A., Gaivão, I., Rego, A., Abreu, H, Pereira, R., Santos, MA., Guilherme, S., Pacheco, M. Protective effects of seaweed feed supplementation against a genotoxic challenge in gilthead seabream (Sparus aurata). (see details)
  30. Guilherme, S. Once upon a time one planet and an herbicide called glyphosate - a wolf in sheep's clothing. (see details)
  1. Guilherme S., Pereira M. E., Santos M. A., Pacheco M. (2010) Mercury distribution in key tissues of caged fish (Liza aurata) along an environmental mercury contamination gradient. Interdisciplinary Studies on Environmental Chemistry Vol.3 (Proceedings). (see details)