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Sofia Isabel Antunes Gomes Guilherme

Sofia Isabel Antunes Gomes Guilherme

Post-Doctoral Research Fellow

  • Department: Biology
  • Research Group: Ecotoxicology
  • ISI Web of KnowledgeSM search factor : AU=(Guilherme S and Pacheco M)
  • Title: Comparação da vulnerabilidade ao dano genético induzido por pesticidas em populações de Procambarus clarkii com diferentes historiais de exposição - Identificação de mecanismos de tolerância e resistência Supervisor: Professor Doutor Mário Pacheco Category: BO Grant type: BPD Funding entity: Fundação para a Ciência e Tecnologia Grant reference: SFRH/BPD/88947/2012 Start date: 2013-11-01 End date: 2019-10-31


Area of scientific activity


  • Aquatic Ecotoxicology

  • Genotoxicity

Academic Degrees


  • 2012, PhD, University of Aveiro

  • 2007, Master in Toxicology, University of Aveiro

  • 2002, First Degree in Biology and Geology, University of Aveiro

Scientific Supervision

In progress
Concluded

Projects

In progress
  • NanoReproTox-Unraveling the ecological impacts of nanoparticles toxicity in the reproduction of marine organisms See more
Concluded
  • GENOPES - Mechanisms of DNA damage induced by pesticides in fish and interference of co-exposure to other contaminants See more

Publications

WoS Papers (21)
Guilherme S., Válega M. , Pereira M.E. , Santos M.A., Pacheco M. (2008) Erythrocytic nuclear abnormalities in wild and caged fish (Liza aurata) along an environmental mercury contamination gradient. In: Ecotoxicology And Environmental Safety. 70 , 3, 411-421.
Guilherme S. , Válega M. , Pereira M.E. , Santos M.A., Pacheco M. (2008) Antioxidant and biotransformation responses in Liza aurata under environmental mercury exposure – relationship with mercury accumulation and implications for public health. In: Marine Pollution Bulletin. 396, 1, 70-78.
Guilherme S. , Gaivao I., Santos M.A., Pacheco M. (2009) Tissue specific DNA damage in the European eel (Anguilla anguilla) following a short-term exposure to a glyphosate-based herbicide. In: Toxicology Letters. 189, Suppl. 1, S212-S212.
Guilherme S. , Gaivão I., Santos M.A., Pacheco M. (2010) European eel (Anguilla anguilla) genotoxic and pro-oxidant responses following short-term exposure to Roundup® - a glyphosate-based herbicide. In: Mutagenesis. 25, 5, 523-530.
Pereira C., Guilherme S., Barroso C., Verschaeve L., Pacheco M., Mendo S. (2010) Evaluation of DNA Damage Induced by Environmental Exposure to Mercury in Liza aurata Using the Comet Assay. In: Archives Of Environmental Contamination And Toxicology. 58, 1, 112-122.
Guilherme S., Gaivão I., Santos M.A., Pacheco M. (2012) DNA damage in fish (Anguilla anguilla) exposed to a glyphosate-based herbicide – Elucidation of organ-specificity and the role of oxidative stress. In: Mutation Research/genetic Toxicology And Environmental Mutagenesis. 743, 1-9.
Costa P., Pereira P., Guilherme S., Barata M., Nicolau L., Santos M.A., Pacheco M., Pousão-Ferreira P. (2012) Biotransformation modulation and genotoxicity in white seabream upon exposure to paralytic shellfish toxins produced by Gymnodinium catenatum. In: Aquatic Toxicology. 106, 42-47.
Guilherme, S., Santos, M.A., Barroso, C., Gaivão, I., Pacheco, M. (2012) Differential genotoxicity of Roundup® formulation and its constituents in blood cells of fish (Anguilla anguilla): considerations on chemical interactions and DNA damaging mechanisms. In: Ecotoxicology. 21, 5, 1381-1390.
Pereira P., Pablo H., Guilherme S., Carvalho S., Santos M.A., Vale C., Pacheco M. (2014) Metal accumulation and oxidative stress responses in Ulva spp. in the presence of nocturnal pulses of metals from sediment: A field transplantation experiment under eutrophic conditions. In: Marine Environmental Research. 94, 56-64.
Guilherme S., Santos M.A., Gaivao I., Pacheco M. (2014) DNA and chromosomal damage induced in fish (Anguilla anguilla L.) by aminomethylphosphonic acid (AMPA)-the major environmental breakdown product of glyphosate. In: Environmental Science And Pollution Research. 21, 14, 8730-8739.
Marques A., Custodio M., Guilherme S., Gaivao I., Santos M.A., Pacheco M. (2014) Assessment of chromosomal damage induced by a deltamethrin-based insecticide in fish (Anguilla anguilla L.) - A follow-up study upon exposure and post-exposure periods. In: Pesticide Biochemistry And Physiology. 113, 40-46.
Marques A., Guilherme S., Gaivao I., Santos M.A., Pacheco M. (2014) Progression of DNA damage induced by a glyphosate-based herbicide in fish (Anguilla anguilla) upon exposure and post-exposure periods - Insights into the mechanisms of genotoxicity and DNA repair. In: Comparative Biochemistry And Physiology C-toxicology & Pharmacology. 166, 126-133.
Guilherme S., Santos M.A., Gaivao I., Pacheco M. (2014) Are DNA-damaging effects induced by herbicide formulations (Roundup (R) and Garlon (R)) in fish transient and reversible upon cessation of exposure?. In: Aquatic Toxicology. 155, 213-221.
Guilherme S., Santos M.A., Gaivao I., Pacheco M. (2015) Genotoxicity evaluation of the herbicide Garlon((R)) and its active ingredient (triclopyr) in fish (Anguilla anguilla L.) using the comet assay. In: Environmental Toxicology. 30, 9, 1073-1081.
Cappello T., Brandao F., Guilherme S., Santos M.A., Maisano M., Mauceri A., Canario J., Pacheco M., Pereira P. (2016) Insights into the mechanisms underlying mercury-induced oxidative stress in gills of wild fish (Liza aurata) combining H-1 NMR metabolomics and conventional biochemical assays. In: Science Of The Total Environment. 548, 13-24.
Marques A., Pilo D., Araujo O., Pereira F., Guilherme S., Carvalho S., Santos M.A., Pacheco M., Pereira P. (2016) Propensity to metal accumulation and oxidative stress responses of two benthic species (Cerastoderma edule and Nephtys hombergii): are tolerance processes limiting their responsiveness?. In: Ecotoxicology. 25, 4, 664-676.
Marques A., Rego A., Guilherme S., Gaivao I., Santos M.A., Pacheco M. (2016) Evidences of DNA and chromosomal damage induced by the mancozeb-based fungicide Mancozan (R) in fish (Anguilla anguilla L.). In: Pesticide Biochemistry And Physiology. 133, 52-58.
Pereira R., Guilherme S., Brandao F., Raimundo J., Santos M.A., Pacheco M., Pereira P. (2016) Insights into neurosensory toxicity of mercury in fish eyes stemming from tissue burdens, oxidative stress and synaptic transmission profiles. In: Marine Environmental Research. 113, 70-79.
Maria V.L., Ribeiro M.J., Guilherme S., Soares A.M.V.M., Scott-Fordsmand J.J., Amorim M.J.B. (2018) Silver (nano)materials Cause Genotoxicity In Enchytraeus crypticus, As Determined By the Comet Assay. In: Environmental Toxicology And Chemistry. 37, 1, 184-191.
Castro D., Mieiro C.L., Coelho J.P., Guilherme S., Marques A., Santos M.A., Duarte A.C., Pereira E., Pacheco M. (2018) Addressing the impact of mercury estuarine contamination in the European eel (Anguilla anguilla L., 1758) - An early diagnosis in glass eel stage based on erythrocytic nuclear morphology. In: Marine Pollution Bulletin. 127, 733-742.
Costa R, Pereira JL, Santos MA, Pacheco M, Guilherme S (in press) The role of contamination history and gender on the genotoxic responses of the crayfish Procambarus clarkii to a penoxsulam-based herbicide - Implications for individuals and populations success. In: Ecotoxicology.
Other Papers (0)
Books (0)
Book Chapter (1)
Luís A., Almeida A, Guilherme S. (2004) International Experiences on Environmental Education: Environmental Education, Comunication and Sustainability. In: Peter Lang GmbH, Frankfurt Main.
Thesis (2)
Guilherme S.A. (2012) Risco genotóxico de herbicidas em Anguilla anguilla L. In: PhD Thesis.
Guilherme S. (2007) Indicadores químicos, bioquímicos e citogenéticos em Liza aurata após exposição ambiental a mercúrio. In: MSc Thesis.
Communications (30)
Mieiro C.L., Guilherme S., Pacheco M., Pereira M.E., Duarte A.C. (2007) Mercury accumulation in Liza aurata along an estuarine contamination gradient. In:
Luís A., Almeida A, Guilherme S. (2003) What do our schoolchildren know about the animal species in their region? First World Environmental Education Congress. In:
Guilherme S., Válega M., Pereira M.E., Santos M.A., Pacheco M. (2007) Genotoxicity of mercury in wild and caged fish (Liza aurata) along an environmental contamination gradient. In:
Guilherme S., Válega M., Pereira M.E., Santos M.A., Pacheco M. (2008) Muscle mercury levels in Liza aurata under environmental exposure and its implications for public health. In:
Guilherme S., Válega M., Pereira M.E., Santos M.A., Pacheco M. (2008) Antioxidant and biotransformation responses in Liza aurata under environmental mercury exposure. In:
Guilherme S., Gaivão I., Santos M. A., Pacheco M. (2009) Tissue specific DNA damage in the European eel (Anguilla anguilla) following a short-term exposure to a glyphosate-based herbicide. In:
Guilherme S., Pereira M. E., Santos M. A., Pacheco M. (2009) Mercury distribution in key tissues of caged fish (Liza aurata) along an environmental mercury contamination gradient. In:
Guilherme S., Gaivão I., Santos M. A., Pacheco M. (2010) Cytogenetic and DNA damage in European eel (Anguilla anguilla) blood following short-term exposure to realistic levels of Roundup® herbicide. In:
Guilherme S., Gaivão I., Santos M. A., Pacheco M. (2010) DNA damage in key tissues of the European eel (Anguilla anguilla) following short-term exposure to Roundup® - a glyphosate-based herbicide. In:
Pereira P., Guilherme S., Pacheco M., Pousão-Ferreira P., Costa P. (2011) Evidences for genotoxicity of paralytic shellfish toxins produced by Gymnodinium catenatum in white seabream (Diplodus sargus) . In:
Costa P., Pereira P., Barata M., Nicolau L., Guilherme S., Pacheco M., Santos M.A., Pousão-Ferreira P. (2010) Liver EROD and GST activities and erythrocytic nuclear abnormalities following intraperitoneal (i.p.) exposure of white seabream (Diplodus sargus) to paralytic shellfish toxins produced by Gymnodinium catenatum. In:
Guilherme S., Ahmad I., Gaivão I., Santos M., Pacheco M. (2012) DNA damage-induced in fish (Anguilla anguilla) by aminomethylphosphonic acid (AMPA) – the major breakdown product of glyphosate. In:
Guilherme S., Ahmad I., Gaivão I., Santos M., Pacheco M. (2012) Genotoxic evaluation of Roundup® formulation and its constituents in fish (Anguilla anguilla). In:
Marques, A., Custódio, M., Guilherme, S., Santos, M.A., Pacheco, M. (2012) Evaluation of cytogenetic damage in peripheral erythrocytes of fish (Anguilla anguilla) upon exposure to a deltamethrin-based insecticide. In:
Guilherme, S., Santos, M.A., Gaivão, I., Pacheco, M. (2012) Genetic damage induced in the European eel (Anguilla anguilla) following short-term exposure to Garlon®, a triclopyr-based herbicide. In:
Guilherme S., Gaivão I., Santos M.A., Pacheco M. (2013) Is DNA damage induced by the herbicide Garlon® in fish (Anguilla anguilla L.) transient and reversible upon cessation of exposure? . In:
Marques A., Rego A., Guilherme S., Santos, M.A., Gaivão I., Pacheco M. (2013) Evaluation of DNA integrity in peripheral erythrocytes of Anguilla anguilla upon short-term exposure to the thiram-based fungicide Pomarsol Ultra D®. In:
Rego A., Marques A., Guilherme S., Santos, M.A., Gaivão I., Pacheco M. (2013) Chromosomal and DNA damage assessment in fish (Anguilla anguilla L.) exposed to Mancozan® - a carbamate fungicide formulation. In:
Guilherme S., Ahmad I., Santos M.A., Gaivão I., Pacheco M. (2012) DNA damage induced in fish (Anguilla anguilla) by aminomethylphosphonic acid (AMPA) - the major breakdown product of glyphosate. In:
Marques, A., Guilherme, S., Gaivão, I., Santos, M. A., Pacheco, M., Genotoxicity and DNA repair induced by a glyphosate-based herbicide in fish upon exposure and post-exposure periods. In:
Marques A., Pereira P., Raimundo J., Araújo O., Barata M., Pousão-Ferreira P., Guilherme S., Santos M.A., Pacheco M. Linking inorganic mercury accumulation in Diplodus sargus blood with the induction of erythrocytic nuclear abnormalities. In:
Araújo, O., Marques, A., Piló, D., Pereira, D., Guilherme, S., Carvalho, S., Pacheco, M., Pereira, P. Searching for associations between mercury sediment loads, accumulated levels in gills and liver of the clam Venerupis philippinarum and oxidative stress profiles. In:
Castro D. ., Mieiro C.L. ., Coelho J.P. ., Guilherme S. ., Marques A. ., Duarte A.C. ., Pereira E. ., Pacheco M. . (2015) Is metal contamination in estuarine environments endangering European eel (Anguilla anguilla) in their first stage in continental waters? . In:
Carvalho S., Pilo D., Marques A., Araújo O., Guilherme S., Leitao A., Pacheco M.P., Pereira P. (2014) Responses of Venerupis philippinarum (Mollusca, Bivalvia) to metal contamination: do they reflect changes at the community level?. In:
Marques, A., Guilherme, S., Gaivão, I., Santos, M. A., Pacheco, M., (2014) Genotoxicity and DNA repair induced by a glyphosate-based herbicide in fish upon exposure and post-exposure periods. In:
Marques A., Pereira P., Raimundo J., Araújo O., Barata M., Pousão-Ferreira P., Guilherme S., Santos M.A., Pacheco M. (2015) Linking inorganic mercury accumulation in Diplodus sargus blood with the induction of erythrocytic nuclear abnormalities. In:
Araújo, O., Marques, A., Piló, D., Pereira, D., Guilherme, S., Carvalho, S., Pacheco, M., Pereira, P. (2015) Searching for associations between mercury sediment loads, accumulated levels in gills and liver of the clam Venerupis philippinarum and oxidative stress profiles. In:
Pereira, R., Guilherme, S., Brandão, F., Santos, M.A., Pacheco, M., Pereira, P. (2015) Insights to neurosensory toxicity of mercury in fish eyes provided by accumulated levels, oxidative stress and acetylcholinesterase profiles. In:
Pereira, V., Marques, A., Gaivão, I., Rego, A., Abreu, H, Pereira, R., Santos, MA., Guilherme, S., Pacheco, M. Protective effects of seaweed feed supplementation against a genotoxic challenge in gilthead seabream (Sparus aurata). In:
Guilherme, S. Once upon a time one planet and an herbicide called glyphosate - a wolf in sheep's clothing. In:
Other Publications (1)
Guilherme S., Pereira M. E., Santos M. A., Pacheco M. (2010) Mercury distribution in key tissues of caged fish (Liza aurata) along an environmental mercury contamination gradient. Interdisciplinary Studies on Environmental Chemistry Vol.3 (Proceedings). In:

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